Dynamische Biomaterialien

We study and orchestrate how synthetic materials interact with living cells. We engineer cell-instructive environments and material-based solutions for zero-waste therapeutic solutions

Our group develops hydrogel materials with programmed and tunable properties designed to encapsulate and instruct living cells. We study how living cells and inert matter interact and how these interactions can be exploited to direct cellular functions and ultimately result in therapeutic advantages. We cooperate with synthetic biologists, biophysicists, drug developers and clinicians to explore the application potential of our developments, with a focus on new materials for ophthalmic drug delivery. We contribute to INM’s competence fields opto-interactive and bio-intelligent materials. Our research addresses biomedical needs.

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Leiterin Dynamische Biomaterialien
Telefon: +49 (0)681-9300-510

Kontakt

Dr. Aleeza Farrukh
Leiterin Biomedizinische Materialien
Telefon: +49 (0)681-9300-315
Dr. Jennifer Yvonne Kasper
Leiterin Bioengineering
Telefon: +49 (0)681-9300-316
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Forschung

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Publikationen

2016
Gauging and tuning cross-linking kinetics of catechol-PEG adhesives via catecholamine functionalization

Paez, Julieta I. | Ustahüseyin, Oya | Serrano, Cristina | Ton, Xuan-Anh | Shafiq, Zahid | Auernhammer, Günter K. | d’Ischia, Marco | del Campo, Aránzazu

Biomacromolecules , 2016, 16 (12), 3811-3818.
http://dx.doi.org/10.1021/acs.biomac.5b01126

1970
Stacked-Layer Heterostructure Films of 2D Thiophene Nanosheets and Graphene for High-Rate All-Solid-State Pseudocapacitors with Enhanced Volumetric Capacitance

Wu, Zhong-Shuai | Zheng, Yijun | Zheng, Shuanghao | Wang, Sen | Sun, Chenglin | Parvez, Khaled | Ikeda, Taichi | Bao, Xinhe | Müllen, Klaus | Feng, Xinliang

Advanced Materials , 1970, 29 (3), 1602960, 1-7.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201602960

OPEN ACCESS Weiterlesen
Guiding cell migration with microscale stiffness patterns and undulated surfaces

Pham, Jonathan T. | Xue, Longjian | del Campo, Aránzazu | Salierno, Marcelo

Acta Biomaterialia , 1970, 38 106-115.
http://dx.doi.org/10.1016/j.actbio.2016.04.031

Surface modification by plasma etching impairs early vascularization and tissue incorporation of porous polyethylene (Medpor®) implants

Laschke, Matthias W. | Augustin, Victor A. | Sahin, Fadime | Anschütz, Dieter | Metzger, Wolfgang | Scheuer, Claudia | Bischoff, Markus | Aktas, Oral C. | Menger, Michael D.

Journal of Biomedical Materials Research Part B: Applied Biomaterials , 1970, 104 (8), 1738-1748.
http://dx.doi.org/10.1002/jbm.b.33528

Bioconjugating thiols to poly(acrylamide) gels for cell culture using methylsulfonyl co-monomers

Farrukh, Aleeza | Paez, Julieta I. | Salierno, Marcelo | del Campo, Aránzazu

Angewandte Chemie-International Edition , 1970, 55 (6), 2092-2096.
http://dx.doi.org/10.1002/anie.201509986

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