Dynamische Biomaterialien

We study and orchestrate how synthetic materials interact with living cells. We engineer cell-instructive environments and material-based solutions for zero-waste therapeutic solutions

Our group develops hydrogel materials with programmed and tunable properties designed to encapsulate and instruct living cells. We study how living cells and inert matter interact and how these interactions can be exploited to direct cellular functions and ultimately result in therapeutic advantages. We cooperate with synthetic biologists, biophysicists, drug developers and clinicians to explore the application potential of our developments, with a focus on new materials for ophthalmic drug delivery. We contribute to INM’s competence fields opto-interactive and bio-intelligent materials. Our research addresses biomedical needs.

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Leiterin Dynamische Biomaterialien
Telefon: +49 (0)681-9300-510

Kontakt

Dr. Aleeza Farrukh
Wissenschaftliche Mitarbeiterin
Telefon: +49 (0)681-9300-315
Dr. Jennifer Yvonne Kasper
Leiterin Bioengineering
Telefon: +49 (0)681-9300-345
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Forschung

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Publikationen

2018
Functional Polymeric Materials Inspired by Geckos, Mussels, and Spider Silk

Yang, Juan | Włodarczyk-Biegun, Małgorzata K. | Filippov, Alexei | Akerboom, Sabine | Dompé, Marco | van Hees, Ilse A. | Mocan, Merve | Kamperman, Marleen

Macromolecular Chemistry and Physics , 2018, 219 (16), 1800051.
https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.201800051

Microenvironments to study migration and somal translocation in cortical neurons

Zhao, Shifang | Fan, Wenqiang | Guo, Xiang | Xue, Longjian | Berninger, Benedikt | Salierno, Marcelo J. | del Campo, Aránzazu

Biomaterials , 2018, 156 238-247.
https://www.sciencedirect.com/science/article/pii/S0142961217307743

Optoregulated Biointerfaces to Trigger Cellular Responses

Zheng, Yijun | Farrukh, Aleeza | del Campo, Aránzazu

Langmuir , 2018, 34 (48), 14459-14471.
https://doi.org/10.1021/acs.langmuir.8b02634

2017
Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis

Farrukh, Aleeza | Ortega, Felipe | Fan, Wenqiang | Marichal, Nicolás | Paez, Julieta I. | Berninger, Benedikt | del Campo, Aranzazu | Salierno, Marcelo J.

Stem Cell Reports , 2017, 9 (5), 1432-1440.
http://www.sciencedirect.com/science/article/pii/S2213671117303855

OPEN ACCESS Weiterlesen
Bifunctional Poly(acrylamide) Hydrogels through Orthogonal Coupling Chemistries

Farrukh, Aleeza | Paez, Julieta I. | Salierno, Marcelo | Fan, Wenqiang | Berninger, Benedikt | del Campo, Aránzazu

Biomacromolecules , 2017, 18 (3), 906-913.
http://dx.doi.org/10.1021/acs.biomac.6b01784

OPEN ACCESS Weiterlesen
Mechanically Reinforced Catechol-Containing Hydrogels with Improved Tissue Gluing Performance

Feng, Jun | Ton, Xuan-Anh | Zhao, Shifang | Paez, Julieta | del Campo, Aránzazu

Biomimetics , 2017, 2 (4), 23.
http://www.mdpi.com/2313-7673/2/4/23

OPEN ACCESS Weiterlesen
Multifunctional Thin Films and Coatings from Caffeic Acid and a Cross-Linking Diamine

Iacomino, Mariagrazia | Paez, Julieta I. | Avolio, Roberto | Carpentieri, Andrea | Panzella, Lucia | Falco, Geppino | Pizzo, Elio | Errico, Maria E. | Napolitano, Alessandra | del Campo, Aranzazu | d’Ischia, Marco

Langmuir , 2017, 33 (9), 2096-2102.
http://dx.doi.org/10.1021/acs.langmuir.6b04079

Cell Adhesion on RGD-Displaying Knottins with Varying Numbers of Tryptophan Amino Acids to Tune the Affinity for Assembly on Cucurbit[8]uril Surfaces

Sankaran, Shrikrishnan | Cavatorta, Emanuela | Huskens, Jurriaan | Jonkheijm, Pascal

Langmuir , 2017, 33 (35), 8813-8820.
http://dx.doi.org/10.1021/acs.langmuir.7b00702

OPEN ACCESS Weiterlesen
Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy

Sankaran, Shrikrishnan | Jaatinen, Leena | Brinkmann, Jenny | Zambelli, Tomaso | Vörös, Janos | Jonkheijm, Pascal

ACS Nano , 2017, 11 (4), 3867-3874.
http://dx.doi.org/10.1021/acsnano.7b00161

OPEN ACCESS Weiterlesen
3D bioprinting of structural proteins

Włodarczyk-Biegun, Małgorzata K. | del Campo, Aránzazu

Biomaterials , 2017, 134 180-201.
http://www.sciencedirect.com/science/article/pii/S0142961217302478

OPEN ACCESS Weiterlesen
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