Dynamische Biomaterialien

We study and orchestrate how synthetic materials interact with living cells. We engineer cell-instructive environments and material-based solutions for zero-waste therapeutic solutions

Our group develops hydrogel materials with programmed and tunable properties designed to encapsulate and instruct living cells. We study how living cells and inert matter interact and how these interactions can be exploited to direct cellular functions and ultimately result in therapeutic advantages. We cooperate with synthetic biologists, biophysicists, drug developers and clinicians to explore the application potential of our developments, with a focus on new materials for ophthalmic drug delivery. We contribute to INM’s competence fields opto-interactive and bio-intelligent materials. Our research addresses biomedical needs.

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Leiterin Dynamische Biomaterialien
Telefon: +49 (0)681-9300-510

Kontakt

Dr. Aleeza Farrukh
Wissenschaftliche Mitarbeiterin
Telefon: +49 (0)681-9300-315
Dr. Jennifer Yvonne Kasper
Leiterin Bioengineering
Telefon: +49 (0)681-9300-316
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Forschung

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Publikationen

2018
Active superelasticity in three-dimensional epithelia of controlled shape

Latorre, Ernest | Kale, Sohan | Casares, Laura | Gómez-González, Manuel | Uroz, Marina | Valon, Léo | Nair, Roshna V. | Garreta, Elena | Montserrat, Nuria | del Campo, Aránzazu | Ladoux, Benoit | Arroyo, Marino | Trepat, Xavier

Nature , 2018, 563 (7730), 203-208.
https://doi.org/10.1038/s41586-018-0671-4

A bio-based route to the carbon-5 chemical glutaric acid and to bionylon-6,5 using metabolically engineered Corynebacterium glutamicum

Rohles, Christina Maria | Gläser, Lars | Kohlstedt, Michael | Gießelmann, Gideon | Pearson, Samuel | del Campo, Aránzazu | Becker, Judith | Wittmann, Christoph

Green Chemistry , 2018, 20 (20), 4662-4674.
http://dx.doi.org/10.1039/C8GC01901K

OPEN ACCESS Weiterlesen
Human Co- and Triple-Culture Model of the Alveolar-Capillary Barrier on a Basement Membrane Mimic

Dohle, Eva | Singh, Smriti | Nishigushi, Akihiro | Fischer, Thorsten | Wessling, Matthias | Möller, Martin | Sader, Robert | Kasper, Jennifer Y. | Ghanaati, Shahram | Kirkpatrick, C. James

Tissue Engineering Part C: Methods , 2018, 24 (9), 495-503.
https://www.liebertpub.com/doi/abs/10.1089/ten.tec.2018.0087

Toward Light-Regulated Living Biomaterials

Sankaran, Shrikrishnan | Zhao, Shifang | Muth, Christina | Paez, Julieta | del Campo, Aránzazu

Advanced Science , 2018, 5 (8), 1800383.
https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.201800383

OPEN ACCESS Weiterlesen
Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth

Farrukh, Aleeza | Fan, Wenqiang | Zhao, Shifang | Salierno, Marcelo | Paez, Julieta I. | Del Campo, Aranzazu

ChemBioChem , 2018, 19 (12), 1271-1279.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800118

A Photoactivatable α5β1-Specific Integrin Ligand

Nair, Roshna V. | Farrukh, Aleeza | del Campo, Aránzazu

ChemBioChem , 2018, 19 (12), 1280-1287.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800180

Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine

Weiss, Ingrid M. | Muth, Christina | Drumm, Robert | Kirchner, Helmut O. K.

BMC Biophysics , 2018, 11 (1), 2.
https://doi.org/10.1186/s13628-018-0042-4

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Cell Adhesion on RGD-Displaying Knottins with Varying Numbers of Tryptophan Amino Acids to Tune the Affinity for Assembly on Cucurbit[8]uril Surfaces

Sankaran, Shrikrishnan | Cavatorta, Emanuela | Huskens, Jurriaan | Jonkheijm, Pascal

Langmuir , 2018, 33 (35), 8813-8820.
http://dx.doi.org/10.1021/acs.langmuir.7b00702

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Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy

Sankaran, Shrikrishnan | Jaatinen, Leena | Brinkmann, Jenny | Zambelli, Tomaso | Vörös, Janos | Jonkheijm, Pascal

ACS Nano , 2018, 11 (4), 3867-3874.
http://dx.doi.org/10.1021/acsnano.7b00161

OPEN ACCESS Weiterlesen
2017
Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis

Farrukh, Aleeza | Ortega, Felipe | Fan, Wenqiang | Marichal, Nicolás | Paez, Julieta I. | Berninger, Benedikt | del Campo, Aranzazu | Salierno, Marcelo J.

Stem Cell Reports , 2017, 9 (5), 1432-1440.
http://www.sciencedirect.com/science/article/pii/S2213671117303855

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