Dynamische Biomaterialien

We study and orchestrate how synthetic materials interact with living cells. We engineer cell-instructive environments and material-based solutions for zero-waste therapeutic solutions

Our group develops hydrogel materials with programmed and tunable properties designed to encapsulate and instruct living cells. We study how living cells and inert matter interact and how these interactions can be exploited to direct cellular functions and ultimately result in therapeutic advantages. We cooperate with synthetic biologists, biophysicists, drug developers and clinicians to explore the application potential of our developments, with a focus on new materials for ophthalmic drug delivery. We contribute to INM’s competence fields opto-interactive and bio-intelligent materials. Our research addresses biomedical needs.

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Leiterin Dynamische Biomaterialien
Telefon: +49 (0)681-9300-510

Kontakt

Dr. Aleeza Farrukh
Leiterin Biomedizinische Materialien
Telefon: +49 (0)681-9300-315
Dr. Jennifer Yvonne Kasper
Leiterin Bioengineering
Telefon: +49 (0)681-9300-316
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Forschung

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Publikationen

2022
Luciferin-Bioinspired Click Ligation Enables Hydrogel Platforms with Fine-Tunable Properties for 3D Cell Culture

Jin, Minye | Koçer, Gülistan | Paez, Julieta I.

ACS Applied Materials & Interfaces , 2022, 14 (4), 5017-5032.
https://doi.org/10.1021/acsami.1c22186

OPEN ACCESS Weiterlesen
Inhibition of Collagenase Q1 of Bacillus cereus as a Novel Antivirulence Strategy for the Treatment of Skin-Wound Infections

Alhayek, Alaa | Khan, Essak S. | Schönauer, Esther | Däinghaus, Tobias | Shafiei, Roya | Voos, Katrin | Han, Mitchell K. L | Ducho, Christian | Posselt, Gernot | Wessler, Silja | Brandstetter, Hans | Haupenthal, Jörg | del Campo, Aránzazu | Hirsch, Anna K. H.

Advanced Therapeutics , 2022, 5 (3), 2100222.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adtp.202100222

OPEN ACCESS Weiterlesen
Dextran-based matrix functionalization to promote WJ-MSCs amplification: synthesis and characterization

Vandeberg, Romain | Grysan, Patrick | Sion, Caroline | Włodarczyk-Biegun, Małgorzata K. | Lentzen, Esther | Bour, Jérôme | Krishnamoorthy, Sivashankar | Olmos, Eric | Grandfils, Christian

International Journal of Polymeric Materials and Polymeric Biomaterials , 2022, 72 (4), 285-295.
https://doi.org/10.1080/00914037.2021.2006657

OPEN ACCESS Weiterlesen
2021
Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting

Puertas-Bartolomé, María | Włodarczyk-Biegun, Małgorzata K. | del Campo, Aránzazu | Vázquez-Lasa, Blanca | San Román, Julio

Materials Science and Engineering: C , 2021, 131 112515.
https://www.sciencedirect.com/science/article/pii/S092849312100655X

OPEN ACCESS Weiterlesen
Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

Pearson, Samuel | Feng, Jun | del Campo, Aránzazu

Advanced Functional Materials , 2021, 31 (50), 2105989.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202105989

OPEN ACCESS Weiterlesen
Engineered living biomaterials

Rodrigo-Navarro, Aleixandre | Sankaran, Shrikrishnan | Dalby, Matthew J. | del Campo, Aránzazu | Salmeron-Sanchez, Manuel

Nature Reviews Materials , 2021, 6 1175–1190.
https://doi.org/10.1038/s41578-021-00350-8

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Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

Zhao, Renping | Zhou, Xiangda | Khan, Essak S. | Alansary, Dalia | Friedmann, Kim S. | Yang, Wenjuan | Schwarz, Eva C. | del Campo, Aránzazu | Hoth, Markus | Qu, Bin

Frontiers in Immunology , 2021, 12 (3309), 729820.
https://www.frontiersin.org/article/10.3389/fimmu.2021.729820

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Optoregulated force application to cellular receptors using molecular motors

Zheng, Yijun | Han, Mitchell K. L. | Zhao, Renping | Blass, Johanna | Zhang, Jingnan | Zhou, Dennis W. | Colard-Itté, Jean-Rémy | Dattler, Damien | Çolak, Arzu | Hoth, Markus | García, Andrés J. | Qu, Bin | Bennewitz, Roland | Giuseppone, Nicolas | del Campo, Aránzazu

Nature Communications , 2021, 12 (1), 3580.
https://doi.org/10.1038/s41467-021-23815-4

OPEN ACCESS Weiterlesen
Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic

Nair, Roshna V. | Farrukh, Aleeza | del Campo, Aránzazu

Advanced Healthcare Materials , 2021, 10 (14), 2100488.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202100488

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Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability

Paez, Julieta I. | de Miguel-Jiménez, Adrián | Valbuena-Mendoza, Rocío | Rathore, Aditi | Jin, Minye | Gläser, Alisa | Pearson, Samuel | del Campo, Aránzazu

Biomacromolecules , 2021, 22 (7), 2874–2886.
https://doi.org/10.1021/acs.biomac.1c00256

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