Dynamische Biomaterialien

We study and orchestrate how synthetic materials interact with living cells. We engineer cell-instructive environments and material-based solutions for zero-waste therapeutic solutions

Our group develops hydrogel materials with programmed and tunable properties designed to encapsulate and instruct living cells. We study how living cells and inert matter interact and how these interactions can be exploited to direct cellular functions and ultimately result in therapeutic advantages. We cooperate with synthetic biologists, biophysicists, drug developers and clinicians to explore the application potential of our developments, with a focus on new materials for ophthalmic drug delivery. We contribute to INM’s competence fields opto-interactive and bio-intelligent materials. Our research addresses biomedical needs.

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Leiterin Dynamische Biomaterialien
Telefon: +49 (0)681-9300-510

Kontakt

Dr. Aleeza Farrukh
Leiterin Biomedizinische Materialien
Telefon: +49 (0)681-9300-315
Dr. Jennifer Yvonne Kasper
Leiterin Bioengineering
Telefon: +49 (0)681-9300-316
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Forschung

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Publikationen

2022
Endothelial cell spreading on lipid bilayers with combined integrin and cadherin binding ligands

Koçer, Gülistan | Albino, Inês M. C. | Verheijden, Mark L. | Jonkheijm, Pascal

Bioorganic & Medicinal Chemistry , 2022, 68 116850.
https://www.sciencedirect.com/science/article/pii/S0968089622002425

OPEN ACCESS Weiterlesen
Melt Electrowriting of Graded Porous Scaffolds to Mimic the Matrix Structure of the Human Trabecular Meshwork

Włodarczyk-Biegun | Villiou, Maria | Koch, Klaus Peter | Muth, Christina | Wang | Ott | del Campo

ACS Biomaterials Science & Engineering , 2022, 8 (9), 3899-3911.
https://pubs.acs.org/doi/10.1021/acsbiomaterials.2c00623

OPEN ACCESS Weiterlesen
Redox-triggerable firefly luciferin-bioinspired hydrogels as injectable and cell-encapsulating matrices

Jin, Minye | Gläser, Alisa | Paez, Julieta I.

Polymer Chemistry , 2022, 13 (35), 5116-5126.
http://dx.doi.org/10.1039/D2PY00481J

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Melt Electrowriting enables fabrication of biommetic hierarchical scaffolds

Wlodarczyk-Biegun, Malgorzata | Zielinski, Piotr | Gladysz, Magdalena | Hofman, Anno | Wu, Xixi | Villiou, Maria | Koch, Marcus | del Campo, Aránzazu | Kamperman, Marleen

Tissue Engineering A , 2022, 28 (Suppl. 1), S362-S362.
https://www.liebertpub.com/doi/epdf/10.1089/ten.tea.2022.29025.abstracts

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Molecular stiffness cues of an interpenetrating network hydrogel for cell adhesion

Li, Bin | Çolak, Arzu | Blass, Johanna | Han, Mitchell | Zhang, Jingnan | Zheng, Yijun | Jiang, Qiyang | Bennewitz, Roland | Campo, Aránzazu del

Materials Today Bio , 2022, 15 100323.
https://www.sciencedirect.com/science/article/pii/S2590006422001211

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Elastomeric Optical Waveguides by Extrusion Printing

Feng, Jun | Zheng, Yijun | Jiang, Qiyang | Włodarczyk-Biegun, Małgorzata K. | Pearson, Samuel | del Campo, Aránzazu

Advanced Materials Technologies , 2022, 7 (10), 2101539.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admt.202101539

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Regulating Bacterial Behavior within Hydrogels of Tunable Viscoelasticity
OPEN ACCESS Weiterlesen
Increasing Antibacterial Efficiency of Cu Surfaces by targeted Surface Functionalization via Ultrashort Pulsed Direct Laser Interference Patterning

Müller, Daniel W. | Lößlein, Sarah | Terriac, Emmanuel | Brix, Kristina | Siems, Katharina | Moeller, Ralf | Kautenburger, Ralf | Mücklich, Frank

Advanced Materials Interfaces , 2022, 8 (5), 2001656.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admi.202001656

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Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand

Yang, Wenjuan | Denger, Andreas | Diener, Caroline | Küppers, Frederic | Soriano-Baguet, Leticia | Schäfer, Gertrud | Yanamandra, Archana K. | Zhao, Renping | Knörck, Arne | Schwarz, Eva C. | Hart, Martin | Lammert, Frank | Roma, Leticia Prates | Brenner, Dirk | Christidis, Grigorios | Helms, Volkhard | Meese, Eckart | Hoth, Markus | Qu, Bin

Frontiers in Immunology , 2022, 13 831680.
https://www.frontiersin.org/article/10.3389/fimmu.2022.831680

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Targeting the Microtubule-network to improve CTL killing capacity in dense 3D matrices

Zhao, Renping | Zhou, Xiangda | Khan, Essak S. | Alansary, Dalia | Friedmann, Kim S. | Yng, Wenjuan | Schwarz, Eva C. | del Campo, Aránzazu | Hoth, Markus | Qu, Bin

European Journal of Immunology , 2022, 51 46.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202170200

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