Remote-controlled drug depots represent a highly valuable tool for the timely controlled administration of pharmaceuticals in a patient compliant manner. Here, the first pharmacologically controlled material that allows for the scheduled induction of a medical response in mice is described. To this aim, a novel, humanized biohybrid material that releases its cargo in response to a small-molecule stimulus licensed for human use is developed. The functionality of the material in mice is demonstrated by the remote-controlled delivery of a vaccine against the oncogenic human papillomavirus type 16. It is shown that the biohybrid depot-mediated immunoprotection is equivalent to the classical multi-injection-based vaccination. These results indicate that this material can be used as a universal remote-controlled vehicle for the patient-compliant delivery of vaccines and pharmaceuticals. A pharmacologically controlled hydrogel depot is presented allowing for the scheduled induction of a medical response in vivo. The vaccine-loaded hydrogel depot is administered to mice. At the desired point in time, the vaccine can be released from the depot by the oral administration of the stimulus molecule fluorescein resulting in protective immunization. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.