Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510

Contact

Dr. Aleeza Farrukh
Stv. Leiterin Dynamische Biomaterialien
Phone: +49 (0)681-9300-315
Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
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Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2017
Multifunctional Thin Films and Coatings from Caffeic Acid and a Cross-Linking Diamine

Iacomino, Mariagrazia | Paez, Julieta I. | Avolio, Roberto | Carpentieri, Andrea | Panzella, Lucia | Falco, Geppino | Pizzo, Elio | Errico, Maria E. | Napolitano, Alessandra | del Campo, Aranzazu | d’Ischia, Marco

Langmuir , 2017, 33 (9), 2096-2102.
http://dx.doi.org/10.1021/acs.langmuir.6b04079

Cell Adhesion on RGD-Displaying Knottins with Varying Numbers of Tryptophan Amino Acids to Tune the Affinity for Assembly on Cucurbit[8]uril Surfaces

Sankaran, Shrikrishnan | Cavatorta, Emanuela | Huskens, Jurriaan | Jonkheijm, Pascal

Langmuir , 2017, 33 (35), 8813-8820.
http://dx.doi.org/10.1021/acs.langmuir.7b00702

OPEN ACCESS Discover more
Cell Adhesion on Dynamic Supramolecular Surfaces Probed by Fluid Force Microscopy-Based Single-Cell Force Spectroscopy

Sankaran, Shrikrishnan | Jaatinen, Leena | Brinkmann, Jenny | Zambelli, Tomaso | Vörös, Janos | Jonkheijm, Pascal

ACS Nano , 2017, 11 (4), 3867-3874.
http://dx.doi.org/10.1021/acsnano.7b00161

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3D bioprinting of structural proteins

Włodarczyk-Biegun, Małgorzata K. | del Campo, Aránzazu

Biomaterials , 2017, 134 180-201.
http://www.sciencedirect.com/science/article/pii/S0142961217302478

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Stacked-Layer Heterostructure Films of 2D Thiophene Nanosheets and Graphene for High-Rate All-Solid-State Pseudocapacitors with Enhanced Volumetric Capacitance

Wu, Zhong-Shuai | Zheng, Yijun | Zheng, Shuanghao | Wang, Sen | Sun, Chenglin | Parvez, Khaled | Ikeda, Taichi | Bao, Xinhe | Müllen, Klaus | Feng, Xinliang

Advanced Materials , 2017, 29 (3), 1602960, 1-7.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adma.201602960

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Hybrid Surface Patterns Mimicking the Design of the Adhesive Toe Pad of Tree Frog

Xue, Longjian | Sanz, Belén | Luo, Aoyi | Turner, Kevin T. | Wang, Xin | Tan, Di | Zhang, Rui | Du, Hang | Steinhart, Martin | Mijangos, Carmen | Guttmann, Markus | Kappl, Michael | del Campo, Aránzazu

ACS Nano , 2017, 11 (10), 9711-9719.
http://dx.doi.org/10.1021/acsnano.7b04994

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2016
Bioconjugating thiols to poly(acrylamide) gels for cell culture using methylsulfonyl co-monomers

Farrukh, Aleeza | Paez, Julieta I. | Salierno, Marcelo | del Campo, Aránzazu

Angewandte Chemie-International Edition , 2016, 55 (6), 2092-2096.
http://dx.doi.org/10.1002/anie.201509986

Monitoring the contact stress distribution of gecko-inspired adhesives using mechano-sensitive surface coatings

Neubauer, Jens Werner | Xue, Longjian | Erath, Johann | Drotlef, Dirk M. | del Campo, Aranzazu | Fery, Andreas

ACS Applied Materials & Interfaces , 2016, 8 (28), 17870-17877.
http://dx.doi.org/10.1021/acsami.6b05327

Guiding cell migration with microscale stiffness patterns and undulated surfaces

Pham, Jonathan T. | Xue, Longjian | del Campo, Aránzazu | Salierno, Marcelo

Acta Biomaterialia , 2016, 38 106-115.
http://dx.doi.org/10.1016/j.actbio.2016.04.031

Phototriggered fibril-like environments arbitrate cell escapes and migration from endothelial monolayers

Salierno, Marcelo J. | García-Fernandez, Luis | Carabelos, Noelia | Kiefer, Karin | García, Andrés J. | del Campo, Aránzazu

Biomaterials , 2016, 82 113-123.
http://dx.doi.org/10.1016/j.biomaterials.2015.12.001

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