Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510

Contact

Dr. Aleeza Farrukh
Deputy Head Dynamic Biomaterials
Phone: +49 (0)681-9300-315
Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
Team Members
Phone: +49 (0)681-9300-181
Phone: +49 (0)681-9300-363
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Phone: +49 (0)681-9300-315
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Phone: +49 (0)681-9300-315
Phone: +49 (0)681-9300-214
Phone: +49 (0)681-9300-363
Phone: +49 (0)681-9300-384
Phone: +49 (0)681-9300-282
Phone: +49 (0)681-9300-152
Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2019
Optoregulated Protein Release from an Engineered Living Material
2018
Human Co- and Triple-Culture Model of the Alveolar-Capillary Barrier on a Basement Membrane Mimic

Dohle, Eva | Singh, Smriti | Nishigushi, Akihiro | Fischer, Thorsten | Wessling, Matthias | Möller, Martin | Sader, Robert | Kasper, Jennifer Y. | Ghanaati, Shahram | Kirkpatrick, C. James

Tissue Engineering Part C: Methods , 2018, 24 (9), 495-503.
https://www.liebertpub.com/doi/abs/10.1089/ten.tec.2018.0087

Photoactivatable Adhesive Ligands for Light-Guided Neuronal Growth

Farrukh, Aleeza | Fan, Wenqiang | Zhao, Shifang | Salierno, Marcelo | Paez, Julieta I. | Del Campo, Aranzazu

ChemBioChem , 2018, 19 (12), 1271-1279.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800118

Microenvironments Designed to Support Growth and Function of Neuronal Cells
OPEN ACCESS Discover more
In Situ, Light-Guided Axon Growth on Biomaterials via Photoactivatable Laminin Peptidomimetic IK(HANBP)VAV

Farrukh, Aleeza | Zhao, Shifang | Paez, Julieta I. | Kavyanifar, Atria | Salierno, Marcelo | Cavalié, Adolfo | del Campo, Aránzazu

ACS Applied Materials & Interfaces , 2018, 10 (48), 41129-41137.
https://doi.org/10.1021/acsami.8b15517

Active superelasticity in three-dimensional epithelia of controlled shape

Latorre, Ernest | Kale, Sohan | Casares, Laura | Gómez-González, Manuel | Uroz, Marina | Valon, Léo | Nair, Roshna V. | Garreta, Elena | Montserrat, Nuria | del Campo, Aránzazu | Ladoux, Benoit | Arroyo, Marino | Trepat, Xavier

Nature , 2018, 563 (7730), 203-208.
https://doi.org/10.1038/s41586-018-0671-4

A Photoactivatable α5β1-Specific Integrin Ligand

Nair, Roshna V. | Farrukh, Aleeza | del Campo, Aránzazu

ChemBioChem , 2018, 19 (12), 1280-1287.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbic.201800180

Toward Light-Regulated Living Biomaterials

Sankaran, Shrikrishnan | Zhao, Shifang | Muth, Christina | Paez, Julieta | del Campo, Aránzazu

Advanced Science , 2018, 5 (8), 1800383.
https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.201800383

OPEN ACCESS Discover more
Thermal decomposition of the amino acids glycine, cysteine, aspartic acid, asparagine, glutamic acid, glutamine, arginine and histidine

Weiss, Ingrid M. | Muth, Christina | Drumm, Robert | Kirchner, Helmut O. K.

BMC Biophysics , 2018, 11 (1), 2.
https://doi.org/10.1186/s13628-018-0042-4

OPEN ACCESS Discover more
Functional Polymeric Materials Inspired by Geckos, Mussels, and Spider Silk

Yang, Juan | Włodarczyk-Biegun, Małgorzata K. | Filippov, Alexei | Akerboom, Sabine | Dompé, Marco | van Hees, Ilse A. | Mocan, Merve | Kamperman, Marleen

Macromolecular Chemistry and Physics , 2018, 219 (16), 1800051.
https://onlinelibrary.wiley.com/doi/abs/10.1002/macp.201800051

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