Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510

Contact

Dr. Aleeza Farrukh
Stv. Leiterin Dynamische Biomaterialien
Phone: +49 (0)681-9300-315
Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
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Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2020
Photodegradable Hydrogels for Cell Encapsulation and Tissue Adhesion

Villiou, Maria | Paez, Julieta I. | del Campo, Aránzazu

ACS Applied Materials & Interfaces , 2020, 12 (34), 37862-37872.
https://doi.org/10.1021/acsami.0c08568

OPEN ACCESS Discover more
Bioinspired footed soft robot with unidirectional all-terrain mobility

Wang, Xin | Yang, Baisong | Tan, Di | Li, Qian | Song, Bin | Wu, Zhong-Shuai | del Campo, Aránzazu | Kappl, Michael | Wang, Zuankai | Gorb, Stanislav N. | Liu, Sheng | Xue, Longjian

Materials Today , 2020, 35 42-49.
http://www.sciencedirect.com/science/article/pii/S1369702120300018

Printability study of metal ion crosslinked PEG-catechol based inks

Włodarczyk-Biegun, Małgorzata K. | Paez, Julieta I. | Villiou, Maria | Feng, Jun | del Campo, Aranzazu

Biofabrication , 2020, 12 (3), 035009.
http://dx.doi.org/10.1088/1758-5090/ab673a

OPEN ACCESS Discover more
Near-infrared-light regulated angiogenesis in a 4D hydrogel

Zheng, Yijun | Chen, Zhijun | Jiang, Qiyang | Feng, Jun | Wu, Si | del Campo, Aránzazu

Nanoscale , 2020, 12 (25), 13654-13661.
http://dx.doi.org/10.1039/D0NR02552F

4D hydrogel for dynamic cell culture with orthogonal, wavelength-dependent mechanical and biochemical cues

Zheng, Yijun | Liong Han, Mitchell Kim | Jiang, Qiyang | Li, Bin | Feng, Jun | del Campo, Aránzazu

Materials Horizons , 2020, 7 111-120.
http://dx.doi.org/10.1039/C9MH00665F

OPEN ACCESS Discover more
2019
The mechanics of single cross-links which mediate cell attachment at a hydrogel surface

Çolak, Arzu | Li, Bin | Blass, Johanna | Koynov, Kaloian | del Campo, Aranzazu | Bennewitz, Roland

Nanoscale , 2019, 11 (24), 11596–11604.
http://dx.doi.org/10.1039/C9NR01784D

Goosebumps-Inspired Microgel Patterns with Switchable Adhesion and Friction

Li, Bin | Kappl, Michael | Han, Lu | Cui, Jiaxi | Zhou, Feng | del Campo, Aránzazu

Small , 2019, 15 (35), 1902376.
https://onlinelibrary.wiley.com/doi/abs/10.1002/smll.201902376

4D Biomaterials for Light-Guided Angiogenesis

Farrukh, Aleeza | Paez, Julieta I. | del Campo, Aránzazu

Advanced Functional Materials , 2019, 29 1807734/1-11.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.201807734

Membrane Tension Orchestrates Rear Retraction in Matrix-Directed Cell Migration

Hetmanski, Joseph H. R. | de Belly, Henry | Busnelli, Ignacio | Waring, Thomas | Nair, Roshna V. | Sokleva, Vanesa | Dobre, Oana | Cameron, Angus | Gauthier, Nils | Lamaze, Christophe | Del Campo, Aránzazu | Starborg, Tobias | Zech, Tobias | Goetz, Jacky G. | Paluch, Ewa K. | Schwartz, Jean-Marc | Caswell, Patrick T.

Developmental Cell , 2019, 51 (4), 460-475.
http://www.sciencedirect.com/science/article/pii/S153458071930735X

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Differentiation of the human liver progenitor cell line (HepaRG) on a microfluidic-based biochip

Jang, Mi | Kleber, Astrid | Ruckelshausen, Thomas | Betzholz, Ralf | Manz, Andreas

Journal of Tissue Engineering and Regenerative Medicine , 2019, 13 (3), 482-494.
https://onlinelibrary.wiley.com/doi/abs/10.1002/term.2802

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