Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510

Contact

Dr. Aleeza Farrukh
Deputy Head Dynamic Biomaterials
Phone: +49 (0)681-9300-315
Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
Team Members
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Phone: +49 (0)681-9300-315
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Phone: +49 (0)681-9300-315
Phone: +49 (0)681-9300-214
Phone: +49 (0)681-9300-363
Phone: +49 (0)681-9300-384
Phone: +49 (0)681-9300-282
Phone: +49 (0)681-9300-152
Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2021
Engineered living biomaterials

Rodrigo-Navarro, Aleixandre | Sankaran, Shrikrishnan | Dalby, Matthew J. | del Campo, Aránzazu | Salmeron-Sanchez, Manuel

Nature Reviews Materials , 2021, 6 1175–1190.
https://doi.org/10.1038/s41578-021-00350-8

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Optoregulated force application to cellular receptors using molecular motors

Zheng, Yijun | Han, Mitchell K. L. | Zhao, Renping | Blass, Johanna | Zhang, Jingnan | Zhou, Dennis W. | Colard-Itté, Jean-Rémy | Dattler, Damien | Çolak, Arzu | Hoth, Markus | García, Andrés J. | Qu, Bin | Bennewitz, Roland | Giuseppone, Nicolas | del Campo, Aránzazu

Nature Communications , 2021, 12 (1), 3580.
https://doi.org/10.1038/s41467-021-23815-4

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Targeting the Microtubule-network to improve CTL killing capacity in dense 3D matrices

Zhao, Renping | Zhou, Xiangda | Khan, Essak S. | Alansary, Dalia | Friedmann, Kim S. | Yng, Wenjuan | Schwarz, Eva C. | del Campo, Aránzazu | Hoth, Markus | Qu, Bin

European Journal of Immunology , 2021, 51 46.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202170200

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Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response

Escolano, Joan-Carles | Taubenberger, Anna V. | Abuhattum, Shada | Schweitzer, Christine | Farrukh, Aleeza | del Campo, Aránzazu | Bryant, Clare E. | Guck, Jochen

Frontiers in Cell and Developmental Biology , 2021, 9 (682),
https://www.frontiersin.org/article/10.3389/fcell.2021.639815

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Increasing Antibacterial Efficiency of Cu Surfaces by targeted Surface Functionalization via Ultrashort Pulsed Direct Laser Interference Patterning

Müller, Daniel W. | Lößlein, Sarah | Terriac, Emmanuel | Brix, Kristina | Siems, Katharina | Moeller, Ralf | Kautenburger, Ralf | Mücklich, Frank

Advanced Materials Interfaces , 2021, 8 (5), 2001656.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admi.202001656

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Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic

Nair, Roshna V. | Farrukh, Aleeza | del Campo, Aránzazu

Advanced Healthcare Materials , 2021, 10 (14), 2100488.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202100488

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Thiol-Methylsulfone-Based Hydrogels for Cell Encapsulation: Reactivity Optimization of Aryl-Methylsulfone Substrate for Fine-Tunable Gelation Rate and Improved Stability

Paez, Julieta I. | de Miguel-Jiménez, Adrián | Valbuena-Mendoza, Rocío | Rathore, Aditi | Jin, Minye | Gläser, Alisa | Pearson, Samuel | del Campo, Aránzazu

Biomacromolecules , 2021, 22 (7), 2874–2886.
https://doi.org/10.1021/acs.biomac.1c00256

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Lighting the Path: Light Delivery Strategies to Activate Photoresponsive Biomaterials In Vivo

Pearson, Samuel | Feng, Jun | del Campo, Aránzazu

Advanced Functional Materials , 2021, 31 (50), 2105989.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adfm.202105989

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Emerging Biofabrication Techniques: A Review on Natural Polymers for Biomedical Applications

Puertas-Bartolomé, María | Mora-Boza, Ana | García-Fernández, Luis

Polymers , 2021, 13 (8), 1209.
https://www.mdpi.com/2073-4360/13/8/1209

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Development of bioactive catechol functionalized nanoparticles applicable for 3D bioprinting

Puertas-Bartolomé, María | Włodarczyk-Biegun, Małgorzata K. | del Campo, Aránzazu | Vázquez-Lasa, Blanca | San Román, Julio

Materials Science and Engineering: C , 2021, 131 112515.
https://www.sciencedirect.com/science/article/pii/S092849312100655X

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