Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510
E-mail: Aranzazu.DelCampo@leibniz-inm.de
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Contact

Dr. Aleeza Farrukh, INM – Leibniz-Institut für Neue Materialien gGmbH
Dr. Aleeza Farrukh
Stv. Leiterin Dynamische Biomaterialien
Phone: +49 (0)681-9300-315
E-mail: aleeza.farrukh@leibniz-inm.de
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Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
E-mail: martina.bonnard@leibniz-inm.de
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Team Members
B.Sc. Israa Abdulrahman Mohammed Kheir Elh
Phone: +49 (0)681-9300-351
E-mail: Israa.Abdulrahman@leibniz-inm.de
Daniel Ablahad
Phone: +49 (0)681-9300-181
E-mail: Daniel.Ablahad@leibniz-inm.de
Britta Abt
Phone: +49 (0)681-9300-363
E-mail: Britta.Abt@leibniz-inm.de
Dr.-Ing. Sener Albayrak
Phone: +49 (0)681-9300-157
E-mail: Sener.Albayrak@leibniz-inm.de
Dr. Gerardo Asensio Martín
Phone: +49 (0)681-9300-315
E-mail: gerardo.asensiomartin@leibniz-inm.de
Dipl.-Chem. Stefan Brück
Phone: +49 (0)681-9300-245
E-mail: stefan.brueck@leibniz-inm.de
B.Sc. Jesús Chong Talavera
Phone: +49 (0)681-9300-108/251
E-mail: jesus.chong@leibniz-inm.de
Semhar Eyob
Phone: +49 (0)681-9300-414
E-mail: semhar.eyob@leibniz-inm.de
M.Sc. Hafiz Syed Usama bin Farrukh
Phone: +49 (0)681-9300-360
E-mail: Usama.Farrukh@leibniz-inm.de
Dr. Aleeza Farrukh
Phone: +49 (0)681-9300-315
E-mail: aleeza.farrukh@leibniz-inm.de
ORCID: https://orcid.org/0000-0002-0711-0419
Dr. Jun Feng
Phone: +49 (0)681-9300-214
E-mail: jun.feng@leibniz-inm.de
M.Sc. Annalena Elisabeth Frank
E-mail: annalena.frank@leibniz-inm.de
B.Sc. Daniel Alfonso Garcia Sanchez
Phone: +49 (0)681-9300-245
E-mail: daniel.sanchez@leibniz-inm.de
Dr. Hannah Jahn-Kelleter
Phone: +49 (0)681-9300-384
E-mail: Hannah.Jahn-Kelleter@leibniz-inm.de
M.Sc. Zahra Kafrashian
Phone: +49 (0)681-9300-237
E-mail: zahra.kafrashian@leibniz-inm.de
ORCID: https://orcid.org/0000-0003-2960-7597
M.Sc. Hanuman Chowdary Kalari
Phone: +49 (0)681-9300-401
E-mail: Hanuman.Kalari@leibniz-inm.de
ORCID: https://orcid.org/0000-0002-2229-317X
Dr. Jennifer Yvonne Kasper
Phone: +49 (0)681-9300-345
E-mail: Jennifer.Kasper@leibniz-inm.de
M.Sc. Mokhamad Khamdan
Phone: +49 (0)681-9300-349
E-mail: mokhamad.khamdan@leibniz-inm.de
Dr. Steffen Krauser
Phone: +49 (0)681-9300-401
E-mail: steffen.krauser@leibniz-inm.de
Dr. Rinku Kumar
Phone: +49 (0)681-9300-316
E-mail: rinku.kumar@leibniz-inm.de
Prof. Dr. Juan Mancebo Aracil
Phone: +49 (0)681-9300-155
E-mail: juan.mancebo@leibniz-inm.de
M.Sc. Joëlle Aurelie Mekontso Ngaffo
Phone: +49 (0)681-9300-247
E-mail: joelle.mekontso@leibniz-inm.de
Dr. Christian Müller
Phone: +49 (0)681-9300-315
E-mail: christian.mueller@leibniz-inm.de
M.Sc. Ann-Cathrin Schlapp
Phone: +49 (0)681-9300-214
E-mail: Ann-Cathrin.Schlapp@leibniz-inm.de
Silke Siegrist
Phone: +49 (0)681-9300-363
E-mail: silke.siegrist@leibniz-inm.de
M.Sc. Therese Steudter
Phone: +49 (0)681-9300-384
E-mail: therese.steudter@leibniz-inm.de
M.Sc. Lara Luana Teruel Enrico
Phone: +49 (0)681-9300-282
E-mail: LaraLuana.TeruelEnrico@leibniz-inm.de
Lennart Weismantel
Phone: +49 (0)681-9300-152
E-mail: lennart.weismantel@leibniz-inm.de
Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2022
Endothelial cell spreading on lipid bilayers with combined integrin and cadherin binding ligands

Koçer, Gülistan | Albino, Inês M. C. | Verheijden, Mark L. | Jonkheijm, Pascal

Bioorganic & Medicinal Chemistry , 2022, 68 116850.
https://www.sciencedirect.com/science/article/pii/S0968089622002425

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Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand

Yang, Wenjuan | Denger, Andreas | Diener, Caroline | Küppers, Frederic | Soriano-Baguet, Leticia | Schäfer, Gertrud | Yanamandra, Archana K. | Zhao, Renping | Knörck, Arne | Schwarz, Eva C. | Hart, Martin | Lammert, Frank | Roma, Leticia Prates | Brenner, Dirk | Christidis, Grigorios | Helms, Volkhard | Meese, Eckart | Hoth, Markus | Qu, Bin

Frontiers in Immunology , 2022, 13 831680.
https://www.frontiersin.org/article/10.3389/fimmu.2022.831680

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2021
Micropatterned soft hydrogels to study the interplay of receptors and forces in T cell activation

Zhang, Jingnan | Zhao, Renping | Li, Bin | Farrukh, Aleeza | Hoth, Markus | Qu, Bin | del Campo, Aránzazu

Acta Biomaterialia , 2021, 119 234-246.
http://www.sciencedirect.com/science/article/pii/S1742706120306176

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Targeting the Microtubule-Network Rescues CTL Killing Efficiency in Dense 3D Matrices

Zhao, Renping | Zhou, Xiangda | Khan, Essak S. | Alansary, Dalia | Friedmann, Kim S. | Yang, Wenjuan | Schwarz, Eva C. | del Campo, Aránzazu | Hoth, Markus | Qu, Bin

Frontiers in Immunology , 2021, 12 (3309), 729820.
https://www.frontiersin.org/article/10.3389/fimmu.2021.729820

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Engineered living biomaterials

Rodrigo-Navarro, Aleixandre | Sankaran, Shrikrishnan | Dalby, Matthew J. | del Campo, Aránzazu | Salmeron-Sanchez, Manuel

Nature Reviews Materials , 2021, 6 1175–1190.
https://doi.org/10.1038/s41578-021-00350-8

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Optoregulated force application to cellular receptors using molecular motors

Zheng, Yijun | Han, Mitchell K. L. | Zhao, Renping | Blass, Johanna | Zhang, Jingnan | Zhou, Dennis W. | Colard-Itté, Jean-Rémy | Dattler, Damien | Çolak, Arzu | Hoth, Markus | García, Andrés J. | Qu, Bin | Bennewitz, Roland | Giuseppone, Nicolas | del Campo, Aránzazu

Nature Communications , 2021, 12 (1), 3580.
https://doi.org/10.1038/s41467-021-23815-4

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Targeting the Microtubule-network to improve CTL killing capacity in dense 3D matrices

Zhao, Renping | Zhou, Xiangda | Khan, Essak S. | Alansary, Dalia | Friedmann, Kim S. | Yng, Wenjuan | Schwarz, Eva C. | del Campo, Aránzazu | Hoth, Markus | Qu, Bin

European Journal of Immunology , 2021, 51 46.
https://onlinelibrary.wiley.com/doi/epdf/10.1002/eji.202170200

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Compliant Substrates Enhance Macrophage Cytokine Release and NLRP3 Inflammasome Formation During Their Pro-Inflammatory Response

Escolano, Joan-Carles | Taubenberger, Anna V. | Abuhattum, Shada | Schweitzer, Christine | Farrukh, Aleeza | del Campo, Aránzazu | Bryant, Clare E. | Guck, Jochen

Frontiers in Cell and Developmental Biology , 2021, 9 (682),
https://www.frontiersin.org/article/10.3389/fcell.2021.639815

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Increasing Antibacterial Efficiency of Cu Surfaces by targeted Surface Functionalization via Ultrashort Pulsed Direct Laser Interference Patterning

Müller, Daniel W. | Lößlein, Sarah | Terriac, Emmanuel | Brix, Kristina | Siems, Katharina | Moeller, Ralf | Kautenburger, Ralf | Mücklich, Frank

Advanced Materials Interfaces , 2021, 8 (5), 2001656.
https://onlinelibrary.wiley.com/doi/abs/10.1002/admi.202001656

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Light-Regulated Angiogenesis via a Phototriggerable VEGF Peptidomimetic

Nair, Roshna V. | Farrukh, Aleeza | del Campo, Aránzazu

Advanced Healthcare Materials , 2021, 10 (14), 2100488.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202100488

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