Dynamic Biomaterials

Prof. Dr. Aránzazu del Campo
Prof. Dr. Aránzazu del Campo
Head of Dynamic Biomaterials
Telefon: +49 (0)681-9300-510

Contact

Dr. Aleeza Farrukh
Deputy Head Dynamic Biomaterials
Phone: +49 (0)681-9300-315
Martina Bonnard
Secretary
Phone: +49 (0)681-9300-397
Team Members
Phone: +49 (0)681-9300-181
Phone: +49 (0)681-9300-363
Phone: +49 (0)681-9300-157
Phone: +49 (0)681-9300-315
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Phone: +49 (0)681-9300-282
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Phone: +49 (0)681-9300-245
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Phone: +49 (0)681-9300-316
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Phone: +49 (0)681-9300-247
Phone: +49 (0)681-9300-315
Phone: +49 (0)681-9300-214
Phone: +49 (0)681-9300-363
Phone: +49 (0)681-9300-384
Phone: +49 (0)681-9300-282
Phone: +49 (0)681-9300-152
Research

Hydrogels with latent properties

By integrating phototriggers and light-responsive molecular motors in polymeric networks, we develop 4D hydrogels with optoregulated (bio)chemical activity, crosslinking, degradation, or mechanoactuation. These are used for biophysical studies of cell response to changes in the biochemical and mechanical signals of the extracellular environment.

Model Cellular Microenvironments

We build synthetic models of cell-matrix and cell-cell interfaces with encoded biochemical, mechanical and dimensional signals. To accelerate discovery, we develop material microarrays for high-throughput biophysical experimentation and apply them to study multifactorial cell responses.

Living Therapeutic Devices

We develop bioinks and apply biofabrication technologies for functional and safe encapsulation of cells in medical devices. We focus on self-replenishable living therapeutic materials which integrate drug biofactories and have unlimited therapeutic release. We aim for innovation in ocular therapeutics with living, self-replenishable drug-eluting contact lenses.

Partner

Selected Publications

2024
Self-Lubricating, Living Contact Lenses

Puertas-Bartolomé, María | Gutierrez-Urrutia, Izabook | Teruel-Enrico, Lara Luana | Nguyen Duong, Cao | Desai, Krupansh | Trujillo, Sara | Wittmann, Christoph | del Campo, Aránzazu

Advanced Materials , 2024, 36 (27), 2313848.
https://onlinelibrary.wiley.com/doi/10.1002/adma.202313848

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Polyacrylamide Hydrogels as Versatile Biomimetic Platforms to Study Cell-Materials Interactions

Milos, Frano | Del Campo, Aránzazu

Advanced Materials Interfaces , 2024, 11 (34), 2400404.
https://onlinelibrary.wiley.com/doi/10.1002/admi.202400404

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2023
Encapsulation of bacteria in bilayer Pluronic thin film hydrogels: A safe format for engineered living materials

Bhusari, Shardul | Kim, Juhyun | Polizzi, Karen | Sankaran, Shrikrishnan | del Campo, Aránzazu

Biomaterials Advances , 2023, 145 213240.
https://www.sciencedirect.com/science/article/pii/S2772950822005179

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In vitro evaluation of immune responses to bacterial hydrogels for the development of living therapeutic materials

Yanamandra, Archana K. | Bhusari, Shardul | del Campo, Aránzazu | Sankaran, Shrikrishnan | Qu, Bin

Biomaterials Advances , 2023, 153 213554.
https://www.sciencedirect.com/science/article/abs/pii/S2772950823002777

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Gelation Kinetics and Mechanical Properties of Thiol-Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation

Miguel-Jiménez, Adrián de | Ebeling, Bastian | Paez, Julieta I | Fink-Straube, Claudia | Pearson, Samuel | del Campo, Aránzazu

Macromolecular Bioscience , 2023, 23 (2), 2200419.
https://onlinelibrary.wiley.com/doi/abs/10.1002/mabi.202200419

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Engineered living materials for the conversion of a low-cost foodgrade precursor to a high-value flavonoid

Riedel, Florian | Puertas Bartolomé, María | Teruel Enrico, Lara Luana | Fink-Straube, Claudia | Nguyen Dong, Cao | Gherlone, Fabio | Huang, Ying | Valiante, Vito | del Campo, Aránzazu | Sankaran, Shrikrishnan

Frontiers in Bioengineering and Biotechnology , 2023, 11 1278062.
https://www.frontiersin.org/articles/10.3389/fbioe.2023.1278062/abstract

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Cytocompatibility evaluation of PEG-methylsulfone hydrogels

Trujillo, Sara | Kasper, Jennifer Y. | Miguel-Jimenez, Adrián De | Abt, Britta | Bauer, Alina | Mekontso Ngaffo, Joelle A. | Pearson, Samuel | del Campo, Aránzazu

ACS Omega , 2023, 8 (35), 32043-32052.
https://pubs.acs.org/doi/10.1021/acsomega.3c03952

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Dextran-based matrix functionalization to promote WJ-MSCs amplification: synthesis and characterization

Vandeberg, Romain | Grysan, Patrick | Sion, Caroline | Włodarczyk-Biegun, Małgorzata K. | Lentzen, Esther | Bour, Jérôme | Krishnamoorthy, Sivashankar | Olmos, Eric | Grandfils, Christian

International Journal of Polymeric Materials and Polymeric Biomaterials , 2023, 72 (4), 285-295.
https://doi.org/10.1080/00914037.2021.2006657

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2022
Molecular stiffness cues of an interpenetrating network hydrogel for cell adhesion

Li, Bin | Çolak, Arzu | Blass, Johanna | Han, Mitchell | Zhang, Jingnan | Zheng, Yijun | Jiang, Qiyang | Bennewitz, Roland | Campo, Aránzazu del

Materials Today Bio , 2022, 15 100323.
https://www.sciencedirect.com/science/article/pii/S2590006422001211

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Regulating Bacterial Behavior within Hydrogels of Tunable Viscoelasticity
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