Electron Microscopy

The Electron Microscopy Core Facility is part of the Innovative Electron Microscopy Department. It ensures day-to-day operation of the electron microscopy facility and provides service to researchers at INM covering a large spectrum of electron microscopy techniques (from sample preparation to image analysis) on a broad variety of samples (from hard hybrid materials to soft hydrogels). The core facility team performs the experiments, assists researchers with their use of the facility equipment, provides training for users, and consults regarding best practices for electron microscopy sample preparation, imaging techniques and image processing.

The Service Group works in close cooperation with different research departments at INM, research groups of Saarland University and other institutions on the Campus. The Service Group is also involved in method development at the Innovative Electron Microscopy Department.

Head of Electron Microscopy

This position is currently vacant.
Please take a look at our job posting

Team Members
Analysis techniques

Analysis techniques offered by the Electron Microscopy Service group:

  • Scanning Electron Microscopy
  • Environmental Scanning Electron Microscopy
  • Focused Ion Beam microscopy and tomography
  • Conventional Transmission Electron Microscopy
  • Transmission Electron Microscopy at cryogenic temperatures
  • X-ray Energy Dispersive Spectroscopy
  • Electron Energy Loss Spectroscopy
  • Electron Backscatter Diffraction
Sample preparation techniques
  • Scanning Electron Microscopy
  • Environmental Scanning Electron Microscopy
  • Focused Ion Beam microscopy and tomography
  • Conventional Transmission Electron Microscopy
  • Transmission Electron Microscopy at cryogenic temperatures
  • X-ray Energy Dispersive Spectroscopy
  • Electron Energy Loss Spectroscopy
  • Electron Backscatter Diffraction

Publications

2021
Scanning electron microscopy preparation of the cellular actin cortex: A quantitative comparison between critical point drying and hexamethyldisilazane drying

Schu, Moritz | Terriac, Emmanuel | Koch, Marcus | Paschke, Stephan | Lautenschläger, Franziska | Flormann, Daniel A.

PLOS ONE , 2021, 16 (7), e0254165-e0254165.
https://pubmed.ncbi.nlm.nih.gov/34234360

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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Schütz, Christian | Ho, Duy-Khiet | Hamed, Mostafa Mohamed | Abdelsamie, Ahmed Saad | Röhrig, Teresa | Herr, Christian | Kany, Andreas Martin | Rox, Katharina | Schmelz, Stefan | Siebenbürger, Lorenz | Wirth, Marius | Börger, Carsten | Yahiaoui, Samir | Bals, Robert | Scrima, Andrea | Blankenfeldt, Wulf | Horstmann, Justus Constantin | Christmann, Rebekka | Murgia, Xabier | Koch, Marcus | Berwanger, Aylin | Loretz, Brigitta | Hirsch, Anna Katharina Herta | Hartmann, Rolf Wolfgang | Lehr, Claus-Michael | Empting, Martin

Advanced Science , 2021, 8 (12), 2004369.
https://onlinelibrary.wiley.com/doi/abs/10.1002/advs.202004369

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Spray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals

Thiyagarajan, Durairaj | Huck, Benedikt | Nothdurft, Birgit | Koch, Marcus | Rudolph, David | Rutschmann, Mark | Feldmann, Claus | Hozsa, Constantin | Furch, Marcus | Besecke, Karen F. W. | Gieseler, Robert K. | Loretz, Brigitta | Lehr, Claus-Michael

Drug Delivery and Translational Research , 2021, 11 (4), 1766-1778.
https://doi.org/10.1007/s13346-021-01011-7

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2020
An environmentally friendly approach to produce single-layer anti-reflective coatings on large surfaces using wet chemical method

Kócs, Lenke | Jilavi, Mohammad H. | Koch, Marcus | Oliveira, Peter William de

Ceramics International , 2020, 46 (16, Part A), 25865-25872.
http://www.sciencedirect.com/science/article/pii/S0272884220320691

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Selective sensing of sulfate anions in water with cyclopeptide-decorated gold nanoparticles

Bartl, Julia | Reinke, Lena | Koch, Marcus | Kubik, Stefan

Chemical Communications , 2020, 56 (72), 10457-10460.
http://dx.doi.org/10.1039/D0CC04796A

Tofacitinib loaded squalenyl nanoparticles for targeted follicular delivery in inflammatory skin diseases

Christmann, Rebekka | Ho, Duy-Khiet | Wilzopolski, Jenny | Lee, Sangeun | Koch, Marcus | Loretz, Brigitta | Vogt, Thomas | Bäumer, Wolfgang | Schaefer, Ulrich F. | Lehr, Claus-Michael

Pharmaceutics , 2020, 12 1131-1-17.
https://doi.org/10.3390/pharmaceutics12121131

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Myxobacteria-Derived Outer Membrane Vesicles: Potential Applicability Against Intracellular Infections

Goes, Adriely | Lapuhs, Philipp | Kuhn, Thomas | Schulz, Eilien | Richter, Robert | Panter, Fabian | Dahlem, Charlotte | Koch, Marcus | Garcia, Ronald | Kiemer, Alexandra K. | Müller, Rolf | Fuhrmann, Gregor

Cells , 2020, 9 (1), 194.
https://www.mdpi.com/2073-4409/9/1/194

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Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Ho, Duy-Khiet | Christmann, Rebekka | Murgia, Xabier | De Rossi, Chiara | Frisch, Sarah | Koch, Marcus | Schaefer, Ulrich F. | Loretz, Brigitta | Desmaele, Didier | Couvreur, Patrick | Lehr, Claus-Michael

Frontiers in Chemistry , 2020, 8 (937),
https://www.frontiersin.org/article/10.3389/fchem.2020.584242

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Squalenyl Hydrogen Sulfate Nanoparticles for Simultaneous Delivery of Tobramycin and an Alkylquinolone Quorum Sensing Inhibitor Enable the Eradication of P. aeruginosa Biofilm Infections

Ho, Duy-Khiet | Murgia, Xabier | De Rossi, Chiara | Christmann, Rebekka | Hüfner de Mello Martins, Antonio G. | Koch, Marcus | Andreas, Anastasia | Herrmann, Jennifer | Müller, Rolf | Empting, Martin | Hartmann, Rolf W. | Desmaele, Didier | Loretz, Brigitta | Couvreur, Patrick | Lehr, Claus-Michael

Angewandte Chemie International Edition , 2020, 59 (26), 10292-10296.
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.202001407

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Targeted delivery of functionalized PLGA nanoparticles to macrophages by complexation with the yeast Saccharomyces cerevisiae

Kiefer, Ruth | Jurisic, Marijas | Dahlem, Charlotte | Koch, Marcus | Schmitt, Manfred J. | Kiemer, Alexandra K. | Schneider, Marc | Breinig, Frank

Biotechnology and Bioengineering , 2020, 117 (3), 776-788.
https://onlinelibrary.wiley.com/doi/abs/10.1002/bit.27226

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