Electron Microscopy

The Electron Microscopy Core Facility is part of the Innovative Electron Microscopy Department. It ensures day-to-day operation of the electron microscopy facility and provides service to researchers at INM covering a large spectrum of electron microscopy techniques (from sample preparation to image analysis) on a broad variety of samples (from hard hybrid materials to soft hydrogels). The core facility team performs the experiments, assists researchers with their use of the facility equipment, provides training for users, and consults regarding best practices for electron microscopy sample preparation, imaging techniques and image processing.

The Service Group works in close cooperation with different research departments at INM, research groups of Saarland University and other institutions on the Campus. The Service Group is also involved in method development at the Innovative Electron Microscopy Department.

Head of Electron Microscopy

This position is currently vacant.
Please take a look at our job posting

Team Members
Analysis techniques

Analysis techniques offered by the Electron Microscopy Service group:

  • Scanning Electron Microscopy
  • Environmental Scanning Electron Microscopy
  • Focused Ion Beam microscopy and tomography
  • Conventional Transmission Electron Microscopy
  • Transmission Electron Microscopy at cryogenic temperatures
  • X-ray Energy Dispersive Spectroscopy
  • Electron Energy Loss Spectroscopy
  • Electron Backscatter Diffraction
Sample preparation techniques
  • Scanning Electron Microscopy
  • Environmental Scanning Electron Microscopy
  • Focused Ion Beam microscopy and tomography
  • Conventional Transmission Electron Microscopy
  • Transmission Electron Microscopy at cryogenic temperatures
  • X-ray Energy Dispersive Spectroscopy
  • Electron Energy Loss Spectroscopy
  • Electron Backscatter Diffraction

Publications

2022
Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Drost, Menka | Diamanti, Eleonora | Fuhrmann, Kathrin | Goes, Adriely | Shams, Atanaz | Haupenthal, Jörg | Koch, Marcus | Hirsch, Anna K. H. | Fuhrmann, Gregor

Pharmaceutics , 2022, 14 (1), 4.
https://www.mdpi.com/1999-4923/14/1/4

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Nano-in-Microparticles for Aerosol Delivery of Antibiotic-Loaded, Fucose-Derivatized, and Macrophage-Targeted Liposomes to Combat Mycobacterial Infections: In Vitro Deposition, Pulmonary Barrier Interactions, and Targeted Delivery

Huck, Benedikt C. | Thiyagarajan, Durairaj | Bali, Aghiad | Boese, Annette | Besecke, Karen F. W. | Hozsa, Constantin | Gieseler, Robert K. | Furch, Marcus | Carvalho-Wodarz, Cristiane | Waldow, Franziska | Schwudke, Dominik | Metelkina, Olga | Titz, Alexander | Huwer, Hanno | Schwarzkopf, Konrad | Hoppstädter, Jessica | Kiemer, Alexandra K. | Koch, Marcus | Loretz, Brigitta | Lehr, Claus-Michael

Advanced Healthcare Materials , 2022, 11 (11), 2102117.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202102117

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Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery to Dendritic Cells: Impact of Lipid Composition on Performance in Different Media

Kliesch, Lena | Delandre, Simon | Gabelmann, Aljoscha | Koch, Marcus | Schulze, Kai | Guzmán, Carlos A. | Loretz, Brigitta | Lehr, Claus-Michael

Pharmaceutics , 2022, 14 (12), 2675.
https://www.mdpi.com/1999-4923/14/12/2675

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The inherent antibiotic activity of myxobacteria-derived autofluorescent outer membrane vesicles is switched on and off by light stimulation

Lapuhs, Philipp | Heinrich, Eilien | Garcia, Ronald | Goes, Adriely | Frank, Nicolas | Bollenbach, Lukas | Stibane, Veronika | Kuhn, Thomas | Koch, Marcus | Kiemer, Alexandra K. | Müller, Rolf | Fuhrmann, Kathrin | Fuhrmann, Gregor

Nanoscale , 2022, 14 (47), 17534-17542.
http://dx.doi.org/10.1039/D2NR02743G

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Yields and Immunomodulatory Effects of Pneumococcal Membrane Vesicles Differ with the Bacterial Growth Phase

Mehanny, Mina | Kroniger, Tobias | Koch, Marcus | Hoppstädter, Jessica | Becher, Dörte | Kiemer, Alexandra K. | Lehr, Claus-Michael | Fuhrmann, Gregor

Advanced Healthcare Materials , 2022, 11 (5), 2101151.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202101151

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Targeting extracellular lectins of Pseudomonas aeruginosa with glycomimetic liposomes

Metelkina, Olga | Huck, Benedikt | O'Connor, Jonathan S. | Koch, Marcus | Manz, Andreas | Lehr, Claus-Michael | Titz, Alexander

Journal of Materials Chemistry B , 2022, 10 (4), 537-548.
http://dx.doi.org/10.1039/D1TB02086B

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Improving the electrical and structural stability of highly piezoresistive nickel–carbon sensor thin films

Schultes, Günter | Cerino, Mario | Lellig, Angela | Koch, Marcus

Journal of Sensors and Sensor Systems , 2022, 11 (1), 137-147.
https://jsss.copernicus.org/articles/11/137/2022/

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Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

Taiarol, Lorenzo | Bigogno, Chiara | Sesana, Silvia | Kravicz, Marcelo | Viale, Francesca | Pozzi, Eleonora | Monza, Laura | Carozzi, Valentina Alda | Meregalli, Cristina | Valtorta, Silvia | Moresco, Rosa Maria | Koch, Marcus | Barbugian, Federica | Russo, Laura | Dondio, Giulio | Steinkühler, Christian | Re, Francesca

Cancers , 2022, 14 (12), 2978.
https://www.mdpi.com/2072-6694/14/12/2978

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Enhancing the Stabilization Potential of Lyophilization for Extracellular Vesicles

Trenkenschuh, Eduard | Richter, Maximilian | Heinrich, Eilien | Koch, Marcus | Fuhrmann, Gregor | Friess, Wolfgang

Advanced Healthcare Materials , 2022, 11 (5), 2100538.
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.202100538

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2021
Micro-Mechanical Response of Ultrafine Grain and Nanocrystalline Tantalum

Yang, Wen | Ruestes, Carlos J. | Li, Zezhou | Abad, Oscar Torrents | Langdon, Terence G. | Heiland, Birgit | Koch, Marcus | Arzt, Eduard | Meyers, Marc A.

Journal of Materials Research and Technology , 2021, 12 1804-1815.
https://www.sciencedirect.com/science/article/pii/S2238785421003070

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