European Journal of Immunology , 2020, 50 (12), 2095-2098.

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation

Zou, Huajiao | Yang, Wenjuan | Schwär, Gertrud | Zhao, Renping | Alansary, Dalia | Yin, Deling | Schwarz, Eva C. | Niemeyer, Barbara | Qu, Bin

In CTLs: High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca2+ influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.

OPEN ACCESS Weiterlesen