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Beitrag in referierter Zeitschrift

Hörner, MaximilianBecker, JanBohnert, RebeccaBanos, MiguelJerez-Longres, CarolinaMühlhäuser, VanessaHärrer, DanielWang Wong, TinMeier, MatthiasWeber, Wilfried. A Photoreceptor-Based Hydrogel with Red Light-Responsive Reversible Sol-Gel Transition as Transient Cellular Matrix. Advanced Materials Technologies 2023, 8 (16), 2300195.

Link: https://onlinelibrary.wiley.com/doi/full/10.1002/admt.202300195

Raute, KatrinStrietz, JulianeParigiani, Maria AlejandraAndrieux, GeoffroyThomas, Oliver S.Kistner, Klaus M.Zintchenko, MarinaAichele, PeterHofmann, MaikeZhou, HoujiangWeber, WilfriedBoerries, MelanieSwamy, MahimaMaurer, JochenMinguet, Susana. Breast Cancer Stem Cell-Derived Tumors Escape from γδ T-cell Immunosurveillance In Vivo by Modulating γδ T-cell Ligands . Cancer Immunology Research 2023, 11 (6), 810-829.

Link: https://aacrjournals.org/cancerimmunolres/article/11/6/810/726519/Breast-Cancer-Stem-Cell-Derived-Tumors-Escape-from

Trehin, Pierre V.M.Munoz-Guamuro, GeislerWeber, Wilfried. Dynamic fine-tuning of CAR-T cell therapy. Molecular Therapy Oncolytics 2023, 30 14-15.

Link: https://www.sciencedirect.com/science/article/pii/S2372770523000414?via%3Dihub

Jerez-Logres, CarolinaGómez-Matos, MarietaBecker, JanHörner, MaximilianWieland, Franz-GeorgTimmer, JensWeber, Wilfried. Engineering a material-genetic interface as safety switch for embedded therapeutic cells. Biomaterials Advances 2023, 150 213422.

Link: https://www.sciencedirect.com/science/article/abs/pii/S2772950823001450?via%3Dihub

Molinari, Pamela E.Krapp, Adriana R.Weiner, AndreaBeyer, Hannes M.Kondadi, Arun KumarBlomeier, TimLópez, MelinaBustos-Sanmamed, PilarTevere, EvelynWeber, WilfriedReichert, Andreas S.Calcaterra, Nora B.Beller, MathiasCarrillo, NestorZurbriggen, Matias D.. NERNST: a genetically-encoded ratiometric non-destructive sensing tool to estimate NADP(H) redox status in bacterial, plant and animal systems. Nature Communications 2023, 14 3277.

Link: https://www.nature.com/articles/s41467-023-38739-4

Fischer, Alexandra A. M.Schatz, LarissaBaaske, JuliaRömer, WinfriedWeber, WilfriedThuenauer, Roland. Real-time monitoring of cell surface protein arrival with split luciferases. Traffic 2023, xxx (xxx), xxx.

Link: https://onlinelibrary.wiley.com/doi/full/10.1111/tra.12908

Su, C.Rodriguez-Franco, M.Lace, B.Nebel, N.Hernandez-Reyes, C.Liang, P.Schulze, E.Mymrikov, E. V.Gross, N. M.Knerr, J.Wang, H.Siukstaite, L.Keller, J.Libourel, C.Fischer, A. A. M.Gabor, K. E.Mark, E.Popp, C.Hunte, C.Weber, WilfriedWendler, P.Stanislas, T.Delaux, P. M.Einsle, O.Grosse, R.Römer, W.Ott, T.. Stabilization of membrane topologies by proteinaceous remorin scaffolds. Nature Communications 2023, 14 (1),

Link: https://dx.doi.org/10.1038/s41467-023-35976-5

Weber, WilfriedFussenegger, M.. The Ramifications of synthetic biology. Current Opinion in Chemical Biology 2023, 73

Link: https://dx.doi.org/10.1016/j.cbpa.2022.102258

Zhou, Y.Kong, D.Wang, X.Yu, G.Wu, X.Guan, N.Weber, WilfriedYe, H.. A small and highly sensitive red/far-red optogenetic switch for applications in mammals. Nature Biotechnology 2022, 40 (2), 262-272.

Link: https://dx.doi.org/10.1038/s41587-021-01036-w

Emig, R.Hoess, P.Cai, H.Kohl, P.Peyronnet, R.Weber, WilfriedHörner, M.. Benchmarking of Cph1 Mutants and DrBphP for Light-Responsive Phytochrome-Based Hydrogels with Reversibly Adjustable Mechanical Properties. Advanced Biology 2022, 6 (7),

Link: https://dx.doi.org/10.1002/adbi.202000337

Ates, H. C.Mohsenin, H.Wenzel, C.Glatz, R. T.Wagner, H. J.Bruch, R.Hoefflin, N.Spassov, S.Streicher, L.Lozano-Zahonero, S.Flamm, B.Trittler, R.Hug, M. J.Köhn, M.Schmidt, J.Schumann, S.Urban, G. A.Weber, WilfriedDincer, C.. Biosensor-Enabled Multiplexed On-Site Therapeutic Drug Monitoring of Antibiotics. Advanced Materials 2022, 34 (2),

Link: https://dx.doi.org/10.1002/adma.202104555

Glatz, R. T.Ates, H. C.Mohsenin, H.Weber, WilfriedDincer, C.. Designing electrochemical microfluidic multiplexed biosensors for on-site applications. Analytical and Bioanalytical Chemistry 2022, 414 (22), 6531-6540.

Link: https://dx.doi.org/10.1007/s00216-022-04210-4

Johnston, M.Ceren Ates, H.Glatz, R. T.Mohsenin, H.Schmachtenberg, R.Göppert, N.Huzly, D.Urban, G. A.Weber, WilfriedDincer, C.. Multiplexed biosensor for point-of-care COVID-19 monitoring: CRISPR-powered unamplified RNA diagnostics and protein-based therapeutic drug management. Materials Today 2022, 61 129-138.

Link: https://dx.doi.org/10.1016/j.mattod.2022.11.001

Meléndez, A. V.Velasco Cárdenas, R. M. H.Lagies, S.Strietz, J.Siukstaite, L.Thomas, O. S.Tomisch, J.Weber, WilfriedKammerer, B.Römer, W.Minguet, S.. Novel lectin-based chimeric antigen receptors target Gb3-positive tumour cells. Cellular and Molecular Life Sciences 2022, 79 (10),

Link: https://dx.doi.org/10.1007/s00018-022-04524-7

Thomas, O. S.Rebmann, B.Tonn, M.Schirmeister, I. C.Wehrle, S.Becker, J.Zea Jimenez, G. J.Hook, S.Jäger, S.Klenzendorf, M.Laskowski, M.Kaier, A.Pütz, G.Zurbriggen, M. D.Weber, WilfriedHörner, M.Wagner, H. J.. Reversible Shielding and Immobilization of Liposomes and Viral Vectors by Tailored Antibody-Ligand Interactions. Small 2022, 18 (6), 2105157.

Link: https://onlinelibrary.wiley.com/doi/10.1002/smll.202105157

Fischer, A. A. M.Kramer, M. M.Radziwill, G.Weber, Wilfried. Shedding light on current trends in molecular optogenetics. Current Opinion in Chemical Biology 2022, 70

Link: https://dx.doi.org/10.1016/j.cbpa.2022.102196

Samanta, A.Hörner, M.Liu, W.Weber, WilfriedWalther, A.. Signal-processing and adaptive prototissue formation in metabolic DNA protocells. Nature Communications 2022, 13 (1),

Link: https://dx.doi.org/10.1038/s41467-022-31632-6

Hörner, M.Weber, Wilfried. Spatially Defined Gene Delivery into Native Cells with the Red Light-Controlled OptoAAV Technology. Current Protocols 2022, 2 (6),

Link: https://dx.doi.org/10.1002/cpz1.440

Liu, A. P.Appel, E. A.Ashby, P. D.Baker, B. M.Franco, E.Gu, L.Haynes, K.Joshi, N. S.Kloxin, A. M.Kouwer, P. H. J.Mittal, J.Morsut, L.Noireaux, V.Parekh, S.Schulman, R.Tang, S. K. Y.Valentine, M. T.Vega, S. L.Weber, WilfriedStephanopoulos, N.Chaudhuri, O.. The living interface between synthetic biology and biomaterial design. Nature Materials 2022, 21 (4), 390-397.

Link: https://dx.doi.org/10.1038/s41563-022-01231-3

Bruch, R.Johnston, M.Kling, A.Mattmüller, T.Baaske, J.Partel, S.Madlener, S.Weber, WilfriedUrban, G. A.Dincer, C.. CRISPR-powered electrochemical microfluidic multiplexed biosensor for target amplification-free miRNA diagnostics. Biosensors and Bioelectronics 2021, 177

Link: https://dx.doi.org/10.1016/j.bios.2020.112887

Yousefi, O. S.Ruggieri, M.Idstein, V.von Prillwitz, K. U.Herr, L. A.Chalupsky, J.Köhn, M.Weber, WilfriedTimmer, J.Schamel, W. W. A.. Cross-TCR antagonism revealed by optogenetically tuning the half-life of the TCR ligand binding. International Journal of Molecular Sciences 2021, 22 (9),

Link: https://dx.doi.org/10.3390/ijms22094920

Schneider, N.Chatelle, C. V.Ochoa-Fernandez, R.Zurbriggen, M. D.Weber, Wilfried. Green Light-Controlled Gene Switch for Mammalian and Plant Cells. Methods in Molecular Biology 2021, 2312 89-107.

Link: https://dx.doi.org/10.1007/978-1-0716-1441-9_6

Schneider, N.Wieland, F. G.Kong, D.Fischer, A. A. M.Hörner, M.Timmer, J.Ye, H.Weber, Wilfried. Liquid-liquid phase separation of light-inducible transcription factors increases transcription activation in mammalian cells and mice. Science Advances 2021, 7 (1),

Link: https://dx.doi.org/10.1126/sciadv.abd3568

Kramer, M. M.Lataster, L.Weber, WilfriedRadziwill, G.. Optogenetic approaches for the spatiotemporal control of signal transduction pathways. International Journal of Molecular Sciences 2021, 22 (10),

Link: https://dx.doi.org/10.3390/ijms22105300

Hörner, M.Weber, Wilfried. Red light-controlled viral gene delivery with single-cell resolution. BioSpektrum 2021, 27 (6), 620-622.

Link: https://dx.doi.org/10.1007/s12268-021-1643-z

Hörner, M.Jerez-Longres, C.Hudek, A.Hook, S.Yousefi, O. S.Schamel, W. W. A.Hörner, C.Zurbriggen, M. D.Ye, H.Wagner, H. J.Weber, Wilfried. Spatiotemporally confined red light-controlled gene delivery at single-cell resolution using adeno-associated viral vectors. Science Advances 2021, 7 (25),

Link: https://dx.doi.org/10.1126/sciadv.abf0797

Burgos-Morales, O.Gueye, M.Lacombe, L.Nowak, C.Schmachtenberg, R.Hörner, M.Jerez-Longres, C.Mohsenin, H.Wagner, H. J.Weber, Wilfried. Synthetic biology as driver for the biologization of materials sciences. Materials Today Bio 2021, 11

Link: https://dx.doi.org/10.1016/j.mtbio.2021.100115

Wagner, H. J.Weber, WilfriedFussenegger, M.. Synthetic Biology: Emerging Concepts to Design and Advance Adeno-Associated Viral Vectors for Gene Therapy. Advanced Science 2021, 8 (9),

Link: https://dx.doi.org/10.1002/advs.202004018

Di Ventura, B.Weber, Wilfried. The Rise of Molecular Optogenetics. Advanced Biology 2021, 5 (5),

Link: https://dx.doi.org/10.1002/adbi.202100776

Thomas, O. S.Hörner, M.Weber, Wilfried. A graphical user interface to design high-throughput optogenetic experiments with the optoPlate-96. Nature Protocols 2020, 15 (9), 2785-2787.

Link: https://dx.doi.org/10.1038/s41596-020-0349-x

Wang, Y.Liao, S.Guan, N.Liu, Y.Dong, K.Weber, WilfriedYe, H.. A versatile genetic control system in mammalian cells and mice responsive to clinically licensed sodium ferulate. Science Advances 2020, 6 (32),

Link: https://dx.doi.org/10.1126/sciadv.abb9484

Meyer, V. K.Chatelle, C. V.Weber, WilfriedNiessner, R.Seidel, M.. Flow-based regenerable chemiluminescence receptor assay for the detection of tetracyclines. Analytical and Bioanalytical Chemistry 2020, 412 (14), 3467-3476.

Link: https://dx.doi.org/10.1007/s00216-019-02368-y

Emig, R.Zgierski-Johnston, C. M.Beyersdorf, F.Rylski, B.Ravens, U.Weber, WilfriedKohl, P.Hörner, M.Peyronnet, R.. Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness. Frontiers in Physiology 2020, 10

Link: https://dx.doi.org/10.3389/fphys.2019.01526

Kramer, M. M.Mühlhäuser, W. W. D.Weber, WilfriedRadziwill, G.. Multichromatic Control of Signaling Pathways in Mammalian Cells. Advanced Biosystems 2020,

Link: https://dx.doi.org/10.1002/adbi.202000196

Ochoa-Fernandez, R.Abel, N. B.Wieland, F. G.Schlegel, J.Koch, L. A.Miller, J. B.Engesser, R.Giuriani, G.Brandl, S. M.Timmer, J.Weber, WilfriedOtt, T.Simon, R.Zurbriggen, M. D.. Optogenetic control of gene expression in plants in the presence of ambient white light. Nature Methods 2020, 17 (7), 717-725.

Link: https://dx.doi.org/10.1038/s41592-020-0868-y

Fischbach, P.Gonschorek, P.Baaske, J.Davies, J. A.Weber, WilfriedZurbriggen, M. D.. Optogenetic Downregulation of Protein Levels to Control Programmed Cell Death in Mammalian Cells with a Dual Blue-Light Switch. Methods in Molecular Biology 2020, 2173 159-170.

Link: https://dx.doi.org/10.1007/978-1-0716-0755-8_11

Lienemann, P. S.Vallmajo-Martin, Q.Papageorgiou, P.Blache, U.Metzger, S.Kiveliö, A. S.Milleret, V.Sala, A.Hoehnel, S.Roch, A.Reuten, R.Koch, M.Naveiras, O.Weber, F. E.Weber, WilfriedLutolf, M. P.Ehrbar, M.. Smart Hydrogels for the Augmentation of Bone Regeneration by Endogenous Mesenchymal Progenitor Cell Recruitment. Advanced Science 2020, 7 (7),

Link: https://dx.doi.org/10.1002/advs.201903395

Hörner, M.Hoess, P.Emig, R.Rebmann, B.Weber, Wilfried. Synthesis of a Light-Controlled Phytochrome-Based Extracellular Matrix with Reversibly Adjustable Mechanical Properties. Methods in Molecular Biology 2020, 2173 217-231.

Link: https://dx.doi.org/10.1007/978-1-0716-0755-8_15

Wagner, H. J.Kemmer, S.Engesser, R.Timmer, J.Weber, Wilfried. Biofunctionalized Materials Featuring Feedforward and Feedback Circuits Exemplified by the Detection of Botulinum Toxin A. Advanced Science 2019, 6 (4), 1801320.

Link: https://dx.doi.org/10.1002/advs.201801320

Bruch, R.Baaske, J.Chatelle, C.Meirich, M.Madlener, S.Weber, WilfriedDincer, C.Urban, G. A.. CRISPR/Cas13a-Powered Electrochemical Microfluidic Biosensor for Nucleic Acid Amplification-Free miRNA Diagnostics. Advanced Materials 2019, 31 (51),

Link: https://dx.doi.org/10.1002/adma.201905311

Wagner, H. J.Weber, Wilfried. Design of a human rhinovirus-14 3C protease-inducible caspase-3. Molecules 2019, 24 (10),

Link: https://dx.doi.org/10.3390/molecules24101945

Kolb, L.Allazetta, S.Karlsson, M.Girgin, M.Weber, WilfriedLutolf, M. P.. High-throughput stem cell-based phenotypic screening through microniches. Biomaterials Science 2019, 7 (8), 3471-3479.

Link: https://dx.doi.org/10.1039/c8bm01180j

Hörner, M.Eble, J.Yousefi, O. S.Schwarz, J.Warscheid, B.Weber, WilfriedSchamel, W. W. A.. Light-controlled affinity purification of protein complexes exemplified by the resting ZAP70 interactome. Frontiers in Immunology 2019, 10 (FEB),

Link: https://dx.doi.org/10.3389/fimmu.2019.00226

Mühlhäuser, W. W. D.Weber, WilfriedRadziwill, G.. OpEn-Tag - A Customizable Optogenetic Toolbox to Dissect Subcellular Signaling. ACS Synthetic Biology 2019, 8 (7), 1679-1684.

Link: https://dx.doi.org/10.1021/acssynbio.9b00059

Baaske, J.Mühlhäuser, W. W. D.Yousefi, O. S.Zanner, S.Radziwill, G.Hörner, M.Schamel, W. W. A.Weber, Wilfried. Optogenetic control of integrin-matrix interaction. Communications Biology 2019, 2 (1),

Link: https://dx.doi.org/10.1038/s42003-018-0264-7

Yousefi, O. S.Günther, M.Hörner, M.Chalupsky, J.Wess, M.Brandl, S. M.Smith, R. W.Fleck, C.Kunkel, T.Zurbriggen, M. D.Höfer, T.Weber, WilfriedSchamel, W. W.. Optogenetic control shows that kinetic proofreading regulates the activity of the t cell receptor. eLife 2019, 8

Link: https://dx.doi.org/10.7554/eLife.42475

Thomas, O. S.Weber, Wilfried. Overcoming Physiological Barriers to Nanoparticle Delivery—Are We There Yet?. Frontiers in Bioengineering and Biotechnology 2019, 7

Link: https://dx.doi.org/10.3389/fbioe.2019.00415

Hörner, M.Raute, K.Hummel, B.Madl, J.Creusen, G.Thomas, O. S.Christen, E. H.Hotz, N.Gübeli, R. J.Engesser, R.Rebmann, B.Lauer, J.Rolauffs, B.Timmer, J.Schamel, W. W. A.Pruszak, J.Römer, W.Zurbriggen, M. D.Friedrich, C.Walther, A.Minguet, S.Sawarkar, R.Weber, Wilfried. Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties. Advanced Materials 2019, 31 (12),

Link: https://dx.doi.org/10.1002/adma.201806727

Hörner, M.Gerhardt, K.Salavei, P.Hoess, P.Härrer, D.Kaiser, J.Tabor, J. J.Weber, Wilfried. Production of Phytochromes by High-Cell-Density E. coli Fermentation. ACS Synthetic Biology 2019, 8 (10), 2442-2450.

Link: https://www.dx.doi.org/10.1021/acssynbio.9b00267

Wagner, H. J.Engesser, R.Ermes, K.Geraths, C.Timmer, J.Weber, Wilfried. Synthetic biology-inspired design of signal-amplifying materials systems. Materials Today 2019, 22 25-34.

Link: https://dx.doi.org/10.1016/j.mattod.2018.04.006

Chatelle, C.Ochoa-Fernandez, R.Engesser, R.Schneider, N.Beyer, H. M.Jones, A. R.Timmer, J.Zurbriggen, M. D.Weber, Wilfried. A Green-Light-Responsive System for the Control of Transgene Expression in Mammalian and Plant Cells. ACS Synthetic Biology 2018, 7 (5), 1349-1358.

Link: https://www.dx.doi.org/10.1021/acssynbio.7b00450

Wagner, H. J.Wehrle, S.Weiss, E.Cavallari, M.Weber, Wilfried. A two-step approach for the design and generation of nanobodies. International Journal of Molecular Sciences 2018, 19 (11),

Link: https://dx.doi.org/10.3390/ijms19113444

Wagner, H. J.Engesser, R.Ermes, K.Geraths, C.Timmer, J.Weber, Wilfried. Characterization of the synthetic biology-inspired implementation of a materials-based positive feedback loop. Data in Brief 2018, 19 665-677.

Link: https://dx.doi.org/10.1016/j.dib.2018.05.074

Middleton, A. M.Dal Bosco, C.Chlap, P.Bensch, R.Harz, H.Ren, F.Bergmann, S.Wend, S.Weber, WilfriedHayashi, K. I.Zurbriggen, M. D.Uhl, R.Ronneberger, O.Palme, K.Fleck, C.Dovzhenko, A.. Data-Driven Modeling of Intracellular Auxin Fluxes Indicates a Dominant Role of the ER in Controlling Nuclear Auxin Uptake. Cell Reports 2018, 22 (11), 3044-3057.

Link: https://dx.doi.org/10.1016/j.celrep.2018.02.074

Baaske, J.Gonschorek, P.Engesser, R.Dominguez-Monedero, A.Raute, K.Fischbach, P.Müller, K.Cachat, E.Schamel, W. W. A.Minguet, S.Davies, J. A.Timmer, J.Weber, WilfriedZurbriggen, M. D.. Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells. Scientific Reports 2018, 8 (1),

Link: https://dx.doi.org/10.1038/s41598-018-32929-7

Beyer, H. M.Thomas, O. S.Riegel, N.Zurbriggen, M. D.Weber, WilfriedHörner, M.. Generic and reversible opto-trapping of biomolecules. Acta Biomaterialia 2018, 79 276-282.

Link: https://dx.doi.org/10.1016/j.actbio.2018.08.032

Schneider, N.Gäbelein, C.Wiener, J.Georgiev, T.Gobet, N.Weber, WilfriedMeier, M.. Genetic Code Expansion Method for Temporal Labeling of Endogenously Expressed Proteins. ACS Chemical Biology 2018, 13 (11), 3049-3053.

Link: https://www.dx.doi.org/10.1021/acschembio.8b00594

Kolar, K.Knobloch, C.Stork, H.Žnidarič, M.Weber, Wilfried. OptoBase: A Web Platform for Molecular Optogenetics. ACS Synthetic Biology 2018, 7 (7), 1825-1828.

Link: https://www.dx.doi.org/10.1021/acssynbio.8b00120

Hörner, M.Chatelle, C.Mühlhäuser, W. W. D.Stocker, D. R.Coats, M.Weber, WilfriedRadziwill, G.. Optogenetic control of focal adhesion kinase signaling. Cellular Signalling 2018, 42 176-183.

Link: https://dx.doi.org/10.1016/j.cellsig.2017.10.012

Beyer, H. M.Engesser, R.Hörner, M.Koschmieder, J.Beyer, P.Timmer, J.Zurbriggen, M. D.Weber, Wilfried. Synthetic Biology Makes Polymer Materials Count. Advanced Materials 2018, 30 (21),

Link: https://dx.doi.org/10.1002/adma.201800472

Fischer, A.Weber, WilfriedWarscheid, B.Radziwill, G.. AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1. Biochimica et Biophysica Acta - Molecular Cell Research 2017, 1864 (1), 89-100.

Link: https://dx.doi.org/10.1016/j.bbamcr.2016.10.009

Bruch, R.Chatelle, C.Kling, A.Rebmann, B.Wirth, S.Schumann, S.Weber, WilfriedDincer, C.Urban, G.. Clinical on-site monitoring of ß-lactam antibiotics for a personalized antibiotherapy. Scientific Reports 2017, 7 (1),

Link: https://dx.doi.org/10.1038/s41598-017-03338-z

Jakob, M. H.Gutsch, S.Chatelle, C.Krishnaraja, A.Fahlteich, J.Weber, WilfriedZacharias, M.. Flexible thin film pH sensor based on low-temperature atomic layer deposition. Physica Status Solidi - Rapid Research Letters 2017, 11 (7),

Link: https://dx.doi.org/10.1002/pssr.201700123

Jakob, M. H.Dong, B.Gutsch, S.Chatelle, C.Krishnaraja, A.Weber, WilfriedZacharias, M.. Label-free SnO2 nanowire FET biosensor for protein detection. Nanotechnology 2017, 28 (24), 245503.

Link: https://dx.doi.org/10.1088/1361-6528/aa7015

Mühlhäuser, W. W. D.Hörner, M.Weber, WilfriedRadziwill, G.. Light-regulated protein kinases based on the CRY2-CIB1 system. Methods in Molecular Biology 2017, 1596 257-270.

Link: https://dx.doi.org/10.1007/978-1-4939-6940-1_16

Hörner, M.Müller, K.Weber, Wilfried. Light-responsive promoters. Methods in Molecular Biology 2017, 1651 173-186.

Link: https://dx.doi.org/10.1007/978-1-4939-7223-4_13

Mühlhäuser, W. W. D.Fischer, A.Weber, WilfriedRadziwill, G.. Optogenetics - Bringing light into the darkness of mammalian signal transduction. Biochimica et Biophysica Acta - Molecular Cell Research 2017, 1864 (2), 280-292.

Link: https://dx.doi.org/10.1016/j.bbamcr.2016.11.009

Kolar, K.Weber, Wilfried. Synthetic biological approaches to optogenetically control cell signaling. Current Opinion in Biotechnology 2017, 47 112-119.

Link: https://dx.doi.org/10.1016/j.copbio.2017.06.010

Metzger, S.Blache, U.Lienemann, P. S.Karlsson, M.Weber, F. E.Weber, WilfriedEhrbar, M.. Cell-Mediated Proteolytic Release of Growth Factors from Poly(Ethylene Glycol) Matrices. Macromolecular Bioscience 2016, 16 (11), 1703-1713.

Link: https://dx.doi.org/10.1002/mabi.201600223

Dincer, C.Kling, A.Chatelle, C.Armbrecht, L.Kieninger, J.Weber, WilfriedUrban, G. A.. Designed miniaturization of microfluidic biosensor platforms using the stop-flow technique. Analyst 2016, 141 (21), 6073-6079.

Link: https://dx.doi.org/10.1021/acs.analchem.6b02294

Kling, A.Chatelle, C.Armbrecht, L.Qelibari, E.Kieninger, J.Dincer, C.Weber, WilfriedUrban, G.. Multianalyte Antibiotic Detection on an Electrochemical Microfluidic Platform. Analytical Chemistry 2016, 88 (20), 10036-10043.

Link: https://dx.doi.org/10.1021/acs.analchem.6b02294

Fischer, A.Warscheid, B.Weber, WilfriedRadziwill, G.. Optogenetic clustering of CNK1 reveals mechanistic insights in RAF and AKT signalling controlling cell fate decisions. Scientific Reports 2016, 6

Link: https://dx.doi.org/10.1038/srep38155

Chatelle, C. V.Hövermann, D.Müller, A.Wagner, H. J.Weber, WilfriedRadziwill, G.. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Scientific Reports 2016, 6

Link: https://dx.doi.org/10.1038/srep23713

Ochoa-Fernandez, R.Samodelov, S. L.Brandl, S. M.Wehinger, E.Müller, K.Weber, WilfriedZurbriggen, M. D.. Optogenetics in plants: Red/Far-Red Light control of gene expression. Methods in Molecular Biology 2016, 1408 125-139.

Link: https://dx.doi.org/10.1007/978-1-4939-3512-3_9

Juillot, S.Beyer, H. M.Madl, J.Weber, WilfriedZurbriggen, M. D.Römer, W.. Signalling to the nucleus under the control of light and small molecules. Molecular BioSystems 2016, 12 (2), 345-349.

Link: https://dx.doi.org/10.1039/c5mb00763a

Samodelov, S. L.Beyer, H. M.Guo, X.Augustin, M.Jia, K. P.Baz, L.Ebenhöh, O.Beyer, P.Weber, WilfriedAl-Babili, S.Zurbriggen, M. D.. Strigoquant: A genetically encoded biosensor for quantifying Strigolactone activity and specificity. Science Advances 2016, 2 (11),

Link: https://dx.doi.org/10.1126/sciadv.1601266

Smith, R. W.Helwig, B.Westphal, A. H.Pel, E.Hörner, M.Beyer, H. M.Samodelov, S. L.Weber, WilfriedZurbriggen, M. D.Borst, J. W.Fleck, C.. Unearthing the transition rates between photoreceptor conformers. BMC Systems Biology 2016, 10 (1),

Link: https://dx.doi.org/10.1186/s12918-016-0368-y

Wagner, H. J.Sprenger, A.Rebmann, B.Weber, Wilfried. Upgrading biomaterials with synthetic biological modules for advanced medical applications. Advanced Drug Delivery Reviews 2016, 105 77-95.

Link: https://dx.doi.org/10.1016/j.addr.2016.05.004

Kolar, K.Wischhusen, H. M.Müller, K.Karlsson, M.Weber, WilfriedZurbriggen, M. D.. A synthetic mammalian network to compute population borders based on engineered reciprocal cell-cell communication. BMC Systems Biology 2015, 9 (1),

Link: https://dx.doi.org/10.1186/s12918-015-0252-1

Müller, K.Zurbriggen, M. D.Weber, Wilfried. An optogenetic upgrade for the Tet-OFF system. Biotechnology and Bioengineering 2015, 112 (7), 1483-1487.

Link: https://dx.doi.org/10.1002/bit.25562

Beyer, H. M.Gonschorek, P.Samodelov, S. L.Meier, M.Weber, WilfriedZurbriggen, M. D.. AQUA cloning: A versatile and simple enzyme-free cloning approach. PLoS ONE 2015, 10 (9),

Link: https://dx.doi.org/10.1371/journal.pone.0137652

Ketterer, S.Hövermann, D.Guebeli, R. J.Bartels-Burgahn, F.Riewe, D.Altmann, T.Zurbriggen, M. D.Junker, B.Weber, WilfriedMeier, M.. Erratum: Transcription Factor Sensor System for Parallel Quantification of Metabolites On-Chip (Anal. Chem.(2014)86 (12152-12158) DOI: 10.1021/ac503269m). Analytical Chemistry 2015, 87 (15), 8034-8034.

Link: https://dx.doi.org/10.1021/acs.analchem.5b02553

Lienemann, P. S.Devaud, Y. R.Reuten, R.Simona, B. R.Karlsson, M.Weber, WilfriedKoch, M.Lutolf, M. P.Milleret, V.Ehrbar, M.. Locally controlling mesenchymal stem cell morphogenesis by 3D PDGF-BB gradients towards the establishment of an in vitro perivascular niche. Integrative Biology (United Kingdom) 2015, 7 (1), 101-111.

Link: https://dx.doi.org/10.1039/c4ib00152d

Metzger, S.Lienemann, P. S.Ghayor, C.Weber, WilfriedMartin, I.Weber, F. E.Ehrbar, M.. Modular poly(ethylene glycol) matrices for the controlled 3D-localized osteogenic differentiation of mesenchymal stem cells. Advanced Healthcare Materials 2015, 4 (4), 550-558.

Link: https://dx.doi.org/10.1002/adhm.201400547

Beyer, H. M.Naumann, S.Weber, WilfriedRadziwill, G.. Optogenetic control of signaling in mammalian cells. Biotechnology Journal 2015, 10 (2), 273-283.

Link: https://dx.doi.org/10.1002/biot.201400077

Müller, K.Naumann, S.Weber, WilfriedZurbriggen, M. D.. Optogenetics for gene expression in mammalian cells. Biological Chemistry 2015, 396 (2), 145-152.

Link: https://dx.doi.org/10.1515/hsz-2014-0199

Beyer, H. M.Juillot, S.Herbst, K.Samodelov, S. L.Müller, K.Schamel, W. W.Römer, W.Schäfer, E.Nagy, F.Strähle, U.Weber, WilfriedZurbriggen, M. D.. Red Light-Regulated Reversible Nuclear Localization of Proteins in Mammalian Cells and Zebrafish. ACS Synthetic Biology 2015, 4 (9), 951-958.

Link: https://www.dx.doi.org/10.1021/acssynbio.5b00004

Ketterer, S.Fuchs, D.Weber, WilfriedMeier, M.. Systematic reconstruction of binding and stability landscapes of the fluorogenic aptamer spinach. Nucleic Acids Research 2015, 43 (19), 9564-9572.

Link: https://dx.doi.org/10.1093/nar/gkv944

Hörner, M.Kaufmann, B.Cotugno, G.Wiedtke, E.Büning, H.Grimm, D.Weber, Wilfried. A chemical switch for controlling viral infectivity. Chemical Communications 2014, 50 (71), 10319-10322.

Link: https://dx.doi.org/10.1039/c4cc03292f

Müller, K.Siegel, D.Rodriguez Jahnke, F.Gerrer, K.Wend, S.Decker, E. L.Reski, R.Weber, WilfriedZurbriggen, M. D.. A red light-controlled synthetic gene expression switch for plant systems. Molecular BioSystems 2014, 10 (7), 1679-1688.

Link: https://dx.doi.org/10.1039/c3mb70579j

Müller, K.Zurbriggen, M. D.Weber, Wilfried. Control of gene expression using a red- and far-red light-responsive bi-stable toggle switch. Nature Protocols 2014, 9 (3), 622-632.

Link: https://dx.doi.org/10.1038/nprot.2014.038

Tomakidi, P.Schulz, S.Proksch, S.Weber, WilfriedSteinberg, T.. Focal adhesion kinase (FAK) perspectives in mechanobiology: implications for cell behaviour. Cell and tissue research 2014, 357 (3), 515-526.

Link: https://dx.doi.org/10.1007/s00441-014-1945-2

Hövermann, D.Rossow, T.Gübeli, R. J.Seiffert, S.Weber, Wilfried. Microfluidic synthesis of pharmacologically responsive supramolecular biohybrid microgels. Macromolecular Bioscience 2014, 14 (12), 1730-1734.

Link: https://dx.doi.org/10.1002/mabi.201400342

Agne, M.Blank, I.Emhardt, A. J.Gäbelein, C. G.Gawlas, F.Gillich, N.Gonschorek, P.Juretschke, T. J.Krämer, S. D.Louis, N.Müller, A.Rudorf, A.Schäfer, L. M.Scheidmann, M. C.Schmunk, L. J.Schwenk, P. M.Stammnitz, M. R.Warmer, P. M.Weber, WilfriedFischer, A.Kaufmann, B.Wagner, H. J.Radziwill, G.. Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation. ACS Synthetic Biology 2014, 3 (12), 986-989.

Link: https://www.dx.doi.org/10.1021/sb500035y

Wend, S.Wagner, H. J.Muller, K.Zurbriggen, M. D.Weber, WilfriedRadziwill, G.. Optogenetic control of protein kinase activity in mammalian cells. ACS Synthetic Biology 2014, 3 (5), 280-285.

Link: https://dx.doi.org/10.1021/sb400090s

Ketterer, S.Hövermann, D.Guebeli, R. J.Bartels-Burgahn, F.Riewe, D.Altmann, T.Zurbriggen, M. D.Junker, B.Weber, WilfriedMeier, M.. Transcription factor sensor system for parallel quantification of metabolites on-chip. Analytical Chemistry 2014, 86 (24), 12152-12158.

Link: https://dx.doi.org/10.1021/ac503269m

Geraths, C.Daoud-El Baba, M.Charpin-El Hamri, G.Weber, Wilfried. A biohybrid hydrogel for the urate-responsive release of urate oxidase. Journal of Controlled Release 2013, 171 (1), 57-62.

Link: https://dx.doi.org/10.1016/j.jconrel.2013.06.037

Karlsson, M.Lienemann, P. S.Sprossmann, N.Heilmann, K.Brummer, T.Lutolf, M. P.Ehrbar, M.Weber, Wilfried. A generic strategy for pharmacological caging of growth factors for tissue engineering. Chemical Communications 2013, 49 (53), 5927-5929.

Link: https://dx.doi.org/10.1039/c3cc41616j

Wend, S.Dal Bosco, C.Kämpf, M. M.Ren, F.Palme, K.Weber, WilfriedDovzhenko, A.Zurbriggen, M. D.. A quantitative ratiometric sensor for time-resolved analysis of auxin dynamics. Scientific Reports 2013, 3

Link: https://dx.doi.org/10.1038/srep02052

Müller, K.Engesser, R.Metzger, S.Schulz, S.Kämpf, M. M.Busacker, M.Steinberg, T.Tomakidi, P.Ehrbar, M.Nagy, F.Timmer, J.Zubriggen, M. D.Weber, Wilfried. A red/far-red light-responsive bi-stable toggle switch to control gene expression in mammalian cells. Nucleic Acids Research 2013, 41 (7),

Link: https://dx.doi.org/10.1093/nar/gkt002

Juillot, S.Weber, Wilfried. Biomedicine of synthesis. Biofutur 2013, (339), 27-30.

Hotz, N.Wilcke, L.Weber, Wilfried. Design, synthesis, and application of stimulus-sensing biohybrid hydrogels. Macromolecular Rapid Communications 2013, 34 (20), 1594-1610.

Link: https://dx.doi.org/10.1002/marc.201300468

Menzel, A.Gübeli, R. J.Güder, F.Weber, WilfriedZacharias, M.. Detection of real-time dynamics of drug-target interactions by ultralong nanowalls. Lab on a Chip 2013, 13 (21), 4173-4179.

Link: https://dx.doi.org/10.1039/c3lc50694k

Bacchus, W.Weber, WilfriedFussenegger, M.. Increasing the dynamic control space of mammalian transcription devices by combinatorial assembly of homologous regulatory elements from different bacterial species. Metabolic Engineering 2013, 15 (1), 144-150.

Link: https://dx.doi.org/10.1016/j.ymben.2012.11.003

Müller, K.Engesser, R.Schulz, S.Steinberg, T.Tomakidi, P.Weber, C. C.Ulm, R.Timmer, J.Zurbriggen, M. D.Weber, Wilfried. Multi-chromatic control of mammalian gene expression and signaling. Nucleic Acids Research 2013, 41 (12),

Link: https://dx.doi.org/10.1093/nar/gkt340

Müller, K.Weber, Wilfried. Optogenetic tools for mammalian systems. Molecular BioSystems 2013, 9 (4), 596-608.

Link: https://dx.doi.org/10.1039/c3mb25590e

Karlsson, M.Rebmann, B.Lienemann, P. S.Sprossmann, N.Ehrbar, M.Radziwill, G.Weber, Wilfried. Pharmacologically controlled protein switch for on-off regulation of growth factor activity. Scientific Reports 2013, 3

Link: https://dx.doi.org/10.1038/srep02716

Gübeli, R. J.Schöneweis, K.Huzly, D.Ehrbar, M.Charpin-El Hamri, G.El-Baba, M. D.Urban, S.Weber, Wilfried. Pharmacologically triggered hydrogel for scheduling hepatitis B vaccine administration. Scientific Reports 2013, 3

Link: https://dx.doi.org/10.1038/srep02610

Gübeli, R. J.Laird, D.Ehrbar, M.Ritter, B. S.Steinberg, T.Tomakidi, P.Weber, Wilfried. Pharmacologically tunable polyethylene-glycol-based cell growth substrate. Acta Biomaterialia 2013, 9 (9), 8272-8278.

Link: https://dx.doi.org/10.1016/j.actbio.2013.05.008

Gübeli, R. J.Hövermann, D.Seitz, H.Rebmann, B.Schoenmakers, R. G.Ehrbar, M.Charpin-El Hamri, G.Daoud-El Baba, M.Werner, M.Müller, M.Weber, Wilfried. Remote-controlled hydrogel depots for time-scheduled vaccination. Advanced Functional Materials 2013, 23 (43), 5355-5362.

Link: https://dx.doi.org/10.1002/adfm.201300875

Geraths, C.Eichstädter, L.Gübeli, R. J.Christen, E. H.Friedrich, C.Weber, Wilfried. Synthesis and characterization of a stimulus-responsive l-ornithine-degrading hydrogel. Journal of Controlled Release 2013, 165 (1), 38-43.

Link: https://dx.doi.org/10.1016/j.jconrel.2012.10.022

Müller, K.Engesser, R.Timmer, J.Zurbriggen, M. D.Nagy, F.Weber, Wilfried. Synthesis of phycocyanobilin in mammalian cells. Chemical Communications 2013, 49 (79), 8970-8972.

Link: https://dx.doi.org/10.1039/c3cc45065a

Gübeli, R. J.Burger, K.Weber, Wilfried. Synthetic biology for mammalian cell technology and materials sciences. Biotechnology Advances 2013, 31 (1), 68-78.

Link: https://dx.doi.org/10.1016/j.biotechadv.2012.01.007

Geraths, C.Christen, E. H.Weber, Wilfried. A hydrogel sensing pathological urate concentrations. Macromolecular Rapid Communications 2012, 33 (24), 2103-2108.

Link: https://dx.doi.org/10.1002/marc.201200563

Alper, H.Weber, Wilfried. Building synthetic cell systems from the ground up. Current Opinion in Biotechnology 2012, 23 (5), 641-643.

Link: https://dx.doi.org/10.1016/j.copbio.2012.07.001

Karlsson, M.Weber, WilfriedFussenegger, M.. Design and construction of synthetic gene networks in mammalian cells. Methods in Molecular Biology 2012, 813 359-376.

Link: https://dx.doi.org/10.1007/978-1-61779-412-4_22

Weber, WilfriedFussenegger, M.. Emerging biomedical applications of synthetic biology. Nature Reviews Genetics 2012, 13 (1), 21-35.

Link: https://dx.doi.org/10.1038/nrg3094

Christen, E. H.Gübeli, R. J.Kaufmann, B.Merkel, L.Schoenmakers, R.Budisa, N.Fussenegger, M.Weber, WilfriedWiltschi, B.. Evaluation of bicinchoninic acid as a ligand for copper(i)-catalyzed azide-alkyne bioconjugations. Organic and Biomolecular Chemistry 2012, 10 (33), 6629-6632.

Link: https://dx.doi.org/10.1039/c2ob25556a

Hörner, M.Weber, Wilfried. Molecular switches in animal cells. FEBS Letters 2012, 586 (15), 2084-2096.

Link: https://dx.doi.org/10.1016/j.febslet.2012.02.032

Haller, C. M.Buerzle, W.Kivelio, A.Perrini, M.Brubaker, C. E.Gubeli, R. J.Mallik, A. S.Weber, WilfriedMessersmith, P. B.Mazza, E.Ochsenbein-Koelble, N.Zimmermann, R.Ehrbar, M.. Mussel-mimetic tissue adhesive for fetal membrane repair: An ex vivo evaluation. Acta Biomaterialia 2012, 8 (12), 4365-4370.

Link: https://dx.doi.org/10.1016/j.actbio.2012.07.047

Zurbriggen, M. D.Moor, A.Weber, Wilfried. Plant and bacterial systems biology as platform for plant synthetic bio(techno)logy. Journal of Biotechnology 2012, 160 (1-2), 80-90.

Link: https://dx.doi.org/10.1016/j.jbiotec.2012.01.014

Weber, WilfriedFussenegger, M.. Preface. Methods in Molecular Biology 2012, 813

Kämpf, M. M.Engesser, R.Busacker, M.Hörner, M.Karlsson, M.Zurbriggen, M. D.Fussenegger, M.Timmer, J.Weber, Wilfried. Rewiring and dosing of systems modules as a design approach for synthetic mammalian signaling networks. Molecular BioSystems 2012, 8 (6), 1824-1832.

Link: https://dx.doi.org/10.1039/c2mb05509k

Gübeli, R. J.Ehrbar, M.Fussenegger, M.Friedrich, C.Weber, Wilfried. Synthesis and characterization of PEG-based drug-responsive biohybrid hydrogels. Macromolecular Rapid Communications 2012, 33 (15), 1280-1285.

Link: https://dx.doi.org/10.1002/marc.201200203

Hörner, M.Reischmann, N.Weber, Wilfried. Synthetic biology: Programming cells for biomedical applications. Perspectives in Biology and Medicine 2012, 55 (4), 490-502.

Link: https://dx.doi.org/10.1353/pbm.2012.0042

Kämpf, M. M.Weber, Wilfried. Synthetic gene networks as Blueprint for smart hydrogels. Methods in Molecular Biology 2012, 813 377-389.

Link: https://dx.doi.org/10.1007/978-1-61779-412-4_23

Jakobus, K.Wend, S.Weber, Wilfried. Synthetic mammalian gene networks as a blueprint for the design of interactive biohybrid materials. Chemical Society Reviews 2012, 41 (3), 1000-1018.

Link: https://dx.doi.org/10.1039/c1cs15176b

Bacchus, W.Lang, M.El-Baba, M. D.Weber, WilfriedStelling, J.Fussenegger, M.. Synthetic two-way communication between mammalian cells. Nature Biotechnology 2012, 30 (10), 991-996.

Link: https://dx.doi.org/10.1038/nbt.2351

Gitzinger, M.Kemmer, C.Fluri, D. A.Daoud El-Baba, M.Weber, WilfriedFussenegger, M.. The food additive vanillic acid controls transgene expression in mammalian cells and mice. Nucleic Acids Research 2012, 40 (5),

Link: https://dx.doi.org/10.1093/nar/gkr1251

Karlsson, M.Weber, Wilfried. Therapeutic synthetic gene networks. Current Opinion in Biotechnology 2012, 23 (5), 703-711.

Link: https://dx.doi.org/10.1016/j.copbio.2012.01.003

Christen, E. H.Karlsson, M.Kämpf, M. M.Schoenmakers, R.Gübeli, R. J.Wischhusen, H. M.Friedrich, C.Fussenegger, M.Weber, Wilfried. Conditional DNA-protein interactions confer stimulus-sensing properties to biohybrid materials. Advanced Functional Materials 2011, 21 (15), 2861-2867.

Link: https://dx.doi.org/10.1002/adfm.201100731

Karlsson, M.Weber, WilfriedFussenegger, M.. De novo design and construction of an inducible gene expression system in mammalian cells. Methods in Enzymology 2011, 497 239-253.

Link: https://doi.org/10.1016/B978-0-12-385075-1.00011-1

Weber, WilfriedFussenegger, M.. Design of Synthetic Mammalian Quorum-Sensing Systems. Methods in Molecular Biology 2011, 692 235-249.

Link: https://dx.doi.org/10.1007/978-1-60761-971-0_17

Weber, WilfriedFussenegger, M.. Molecular diversity-the toolbox for synthetic gene switches and networks. Current Opinion in Chemical Biology 2011, 15 (3), 414-420.

Link: https://dx.doi.org/10.1016/j.cbpa.2011.03.003

Wend, S.Weber, Wilfried. Synthetic biology: Synthetic ecosystems. BioSpektrum 2011, 17 (4), 405-407.

Link: https://dx.doi.org/10.1007/s12268-011-0063-x

Kämpf, M. M.Christen, E. H.Ehrbar, M.Baba, M. D. E.Hamri, G. C. E.Fussenegger, M.Weber, Wilfried. A gene therapy technology-based biomaterial for the trigger-inducible release of biopharmaceuticals in mice. Advanced Functional Materials 2010, 20 (15), 2534-2538.

Link: https://dx.doi.org/10.1002/adfm.200902377

Kämpf, M. M.Christen, E. H.Weber, Wilfried. Biohybrid materials: Materials for the inducible release of biopharmaceuticals. BioSpektrum 2010, 16 (6), 671-672.

Link: https://www.biospektrum.de/magazinartikel/materialien-zur-induzierbaren-freisetzung-von-biopharmazeutika

Kämpf, M. M.Weber, Wilfried. Synthetic biology in the analysis and engineering of signaling processes. Integrative Biology 2010, 2 (1), 12-24.

Link: https://dx.doi.org/10.1039/b913490e

Weber, WilfriedFussenegger, M.. Synthetic gene networks in mammalian cells. Current Opinion in Biotechnology 2010, 21 (5), 690-696.

Link: https://dx.doi.org/10.1016/j.copbio.2010.07.006

Weber, WilfriedLienhart, C.Daoud-El Baba, M.Fussenegger, M.. A biotin-triggered genetic switch in mammalian cells and mice. Metabolic Engineering 2009, 11 (2), 117-124.

Link: https://dx.doi.org/10.1016/j.ymben.2008.12.001

Christen, E. H.Karlsson, M.Kämpf, M. M.Weber, C. C.Fussenegger, M.Weber, Wilfried. A general strategy for the production of difficult-to-express inducer-dependent bacterial repressor proteins in Escherichia coli. Protein Expression and Purification 2009, 66 (2), 158-164.

Link: https://dx.doi.org/10.1016/j.pep.2009.03.007

Weber, WilfriedLuzi, S.Karlsson, M.Fussenegger, M.. A novel hybrid dual-channel catalytic-biological sensor system for assessment of fruit quality. Journal of Biotechnology 2009, 139 (4), 314-317.

Link: https://dx.doi.org/10.1016/j.jbiotec.2009.01.002

Weber, WilfriedLuzi, S.Karlsson, M.Sanchez-Bustamante, C. D.Frey, U.Hierlemann, A.Fussenegger, M.. A synthetic mammalian electro-genetic transcription circuit. Nucleic Acids Research 2009, 37 (4),

Link: https://dx.doi.org/10.1093/nar/gkp014

Weber, WilfriedSchuetz, M.Dénervaud, N.Fussenegger, M.. A synthetic metabolite-based mammalian inter-cell signaling system. Molecular BioSystems 2009, 5 (7), 757-763.

Link: https://dx.doi.org/10.1039/b902070p

Gitzinger, M.Kemmer, C.El-Baba, M. D.Weber, WilfriedFussenegger, M.. Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin. Proceedings of the National Academy of Sciences of the United States of America 2009, 106 (26), 10638-10643.

Link: https://dx.doi.org/10.1073/pnas.0901501106

Weber, WilfriedFussenegger, M.. Engineering of Synthetic Mammalian Gene Networks. Chemistry and Biology 2009, 16 (3), 287-297.

Link: https://dx.doi.org/10.1016/j.chembiol.2009.02.005

Weber, WilfriedLienhart, C.Daoud-El Baba, M.Grass, R. N.Kohler, T.Müller, R.Stark, W. J.Fussenegger, M.. Magnet-guided transduction of mammalian cells and mice using engineered magnetic lentiviral particles. Journal of Biotechnology 2009, 141 (3-4), 118-122.

Link: https://dx.doi.org/10.1016/j.jbiotec.2009.02.023

Weber, WilfriedFussenegger, M.. The impact of synthetic biology on drug discovery. Drug Discovery Today 2009, 14 (19-20), 956-963.

Link: https://dx.doi.org/10.1016/j.drudis.2009.06.010

Weber, WilfriedSchoenmakers, R.Keller, B.Gitzinger, M.Grau, T.Baba, M. D. E.Sander, P.Fussenegger, M.. A synthetic mammalian gene circuit reveals antituberculosis compounds. Proceedings of the National Academy of Sciences of the United States of America 2008, 105 (29), 9994-9998.

Link: https://dx.doi.org/10.1073/pnas.0800663105

Ehrbar, M.Schoenmakers, R.Christen, E. H.Fussenegger, M.Weber, Wilfried. Drug-sensing hydrogels for the inducible release of biopharmaceuticals. Nature Materials 2008, 7 (10), 800-804.

Link: https://dx.doi.org/10.1038/nmat2250

Werner, N. S.Weber, WilfriedFussenegger, M.Geisse, S.. A gas-inducible expression system in HEK.EBNA cells applied to controlled proliferation studies by expression of p27Kip1. Biotechnology and Bioengineering 2007, 96 (6), 1155-1166.

Link: https://dx.doi.org/10.1002/bit.21235

Weber, WilfriedKramer, B. P.Fussenegger, M.. A genetic time-delay circuitry in mammalian cells. Biotechnology and Bioengineering 2007, 98 (4), 894-902.

Link: https://dx.doi.org/10.1002/bit.21463

Link, N.Weber, WilfriedFussenegger, M.. A novel generic dipstick-based technology for rapid and precise detection of tetracycline, streptogramin and macrolide antibiotics in food samples. Journal of Biotechnology 2007, 128 (3), 668-680.

Link: https://dx.doi.org/10.1016/j.jbiotec.2006.11.011

Weber, WilfriedBacchus, W.Gruber, F.Hamberger, M.Fussenegger, M.. A novel vector platform for vitamin H-inducible transgene expression in mammalian cells. Journal of Biotechnology 2007, 131 (2), 150-158.

Link: https://dx.doi.org/10.1016/j.jbiotec.2007.06.008

Weber, WilfriedStelling, J.Rimann, M.Keller, B.Daoud-El Baba, M.Weber, C. C.Aubel, D.Fussenegger, M.. A synthetic time-delay circuit in mammalian cells and mice. Proceedings of the National Academy of Sciences of the United States of America 2007, 104 (8), 2643-2648.

Link: https://dx.doi.org/10.1073/pnas.0606398104

Hartenbach, S.Daoud-El Baba, M.Weber, WilfriedFussenegger, M.. An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice. Nucleic Acids Research 2007, 35 (20),

Link: https://dx.doi.org/10.1093/nar/gkm652

Weber, WilfriedFussenegger, M.. Inducible product gene expression technology tailored to bioprocess engineering. Current Opinion in Biotechnology 2007, 18 (5), 399-410.

Link: https://dx.doi.org/10.1016/j.copbio.2007.09.002

Weber, WilfriedLink, N.Aubel, D.Weber, C. C.Fussenegger, M.. RepTAGs: Universal tags for isolation and labeling of proteins, for labeling live mammalian cells and for drug discovery. Biotechnology and Bioengineering 2007, 98 (6), 1276-1287.

Link: https://dx.doi.org/10.1002/bit.21485

Weber, WilfriedDaoud-El Baba, M.Fussenegger, M.. Synthetic ecosystems based on airborne inter- and intrakingdom communication. Proceedings of the National Academy of Sciences of the United States of America 2007, 104 (25), 10435-10440.

Link: https://dx.doi.org/10.1073/pnas.0701382104

Weber, WilfriedBacchus, W.Daoud-El Baba, M.Fussenegger, M.. Vitamin H-regulated transgene expression in mammalian cells. Nucleic Acids Research 2007, 35 (17),

Link: https://dx.doi.org/10.1093/nar/gkm466

Weber, WilfriedLink, N.Fussenegger, M.. A genetic redox sensor for mammalian cells. Metabolic Engineering 2006, 8 (3), 273-280.

Link: https://dx.doi.org/10.1016/j.ymben.2005.12.004

Weber, WilfriedRimann, M.Schafroth, T.Witschi, U.Fussenegger, M.. Design of high-throughput-compatible protocols for microencapsulation, cryopreservation and release of bovine spermatozoa. Journal of Biotechnology 2006, 123 (2), 155-163.

Link: https://dx.doi.org/10.1016/j.jbiotec.2005.11.008

Weber, WilfriedFussenegger, M.. Pharmacologic transgene control systems for gene therapy. Journal of Gene Medicine 2006, 8 (5), 535-556.

Link: https://dx.doi.org/10.1002/jgm.903

Link, N.Aubel, C.Kelm, J. M.Marty, R. R.Greber, D.Djonov, V.Bourhis, J.Weber, WilfriedFussenegger, M.. Therapeutic protein transduction of mammalian cells and mice by nucleic acid-free lentiviral nanoparticles. Nucleic Acids Research 2006, 34 (2), 1-10.

Link: https://dx.doi.org/10.1093/nar/gnj014

Malphettes, L.Weber, C. C.El-Baba, M. D.Schoenmakers, R. G.Aubel, D.Weber, WilfriedFussenegger, M.. A novel mammalian expression system derived from components coordinating nicotine degradation in arthrobacter nicotinovorans pAO1. Nucleic Acids Research 2005, 33 (12), 1-13.

Link: https://dx.doi.org/10.1093/nar/gni107

Weber, C. C.Link, N.Fux, C.Zisch, A. H.Weber, WilfriedFussenegger, M.. Broad-spectrum protein biosensors for class-specific detection of antibiotics. Biotechnology and Bioengineering 2005, 89 (1), 9-17.

Link: https://dx.doi.org/10.1002/bit.20224

Weber, C. C.Cai, H.Ehrbar, M.Kubota, H.Martiny-Baron, G.Weber, WilfriedDjonov, V.Weber, E.Mallik, A. S.Fussenegger, M.Frei, K.Hubbell, J. A.Zisch, A. H.. Effects of protein and gene transfer of the angiopoietin-1 fibrinogen-like receptor-binding domain on endothelial and vessel organization. Journal of Biological Chemistry 2005, 280 (23), 22445-22453.

Link: https://dx.doi.org/10.1074/jbc.M410367200

Weber, WilfriedMalphettes, L.de Jesus, M.Schoenmakers, R.El-Baba, M. D.Spielmann, M.Keller, B.Weber, C. C.van de Wetering, P.Aubel, D.Wurm, F. M.Fussenegger, M.. Engineered Streptomyces quorum-sensing components enable inducible siRNA-mediated translation control im mammalian cells and adjustable transcription control in mice. Journal of Gene Medicine 2005, 7 (4), 518-525.

Link: https://dx.doi.org/10.1002/jgm.682

Weber, WilfriedRimann, M.De Glutz, F. N.Weber, E.Memmert, K.Fussenegger, M.. Gas-inducible product gene expression in bioreactors. Metabolic Engineering 2005, 7 (3), 174-181.

Link: https://dx.doi.org/10.1016/j.ymben.2005.01.003

Weber, WilfriedMalphettes, L.Rinderknecht, M.Schoenmakers, R. G.Spielmann, M.Keller, B.Van De Wetering, P.Weber, C. C.Fussenegger, M.. Quorum-sensing-based toolbox for regulatable transgene and siRNA expression in mammalian cells. Biotechnology Progress 2005, 21 (1), 178-185.

Link: https://dx.doi.org/10.1021/bp0498995

Weber, WilfriedSpielmann, M.El-Baba, M. D.Keller, B.Aubel, D.Fussenegger, M.. Tobacco smoke as inducer for gas phase-controlled transgene expression in mammalian cells and mice. Biotechnology and Bioengineering 2005, 90 (7), 893-897.

Link: https://dx.doi.org/10.1002/bit.20482

Kramer, B. P.Viretta, A. U.Baba, M. D. E.Aubel, D.Weber, WilfriedFussenegger, M.. An engineered epigenetic transgene switch in mammalian cells. Nature Biotechnology 2004, 22 (7), 867-870.

Link: https://dx.doi.org/10.1038/nbt980

Weber, WilfriedFussenegger, M.. Approaches for trigger-inducible viral transgene regulation in gene-based tissue engineering. Current Opinion in Biotechnology 2004, 15 (5), 383-391.

Link: https://dx.doi.org/10.1016/j.copbio.2004.07.003

Weber, WilfriedRinderknecht, M.Baba, M. D. E.Glutz, F. N. D.Aubel, D.Fussenegger, M.. CellMAC: A novel technology for encapsulation of mammalian cells in cellulose sulfate/pDADMAC capsules assembled on a transient alginate/Ca 2+ scaffold. Journal of Biotechnology 2004, 114 (3), 315-326.

Link: https://dx.doi.org/10.1016/j.jbiotec.2004.07.014

Fux, C.Langer, D.Kelm, J. M.Weber, WilfriedFussenegger, M.. Erratum: New-generation multicistronic expression platform: pTRIDENT vectors containing size-optimized IRES elements enable homing endonuclease-based cistron swapping into lenitviral expression vectors (Biotechnology and Bioengineering (2004) 86 (174-187)). Biotechnology and Bioengineering 2004, 86 (5), 600.

Link: https://dx.doi.org/10.1002/bit.20164

Weber, WilfriedRimann, M.Spielmann, M.Keller, B.Daoud-El Baba, M.Aubel, D.Weber, C. C.Fussenegger, M.. Gas-inducible transgene expression in mammalian cells and mice. Nature Biotechnology 2004, 22 (11), 1440-1444.

Link: https://dx.doi.org/10.1038/nbt1021

Weber, WilfriedFussenegger, M.. Inducible gene expression in mammalian cells and mice. Methods in molecular biology 2004, 267 451-466.

Link: https://dx.doi.org/10.1385/1-59259-774-2:451

Fux, C.Langer, D.Kelm, J. M.Weber, WilfriedFussenegger, M.. New-Generation Multicistronic Expression Platform: pTRIDENT Vectors Containing Size-Optimized IRES Elements Enable Homing Endonuclease-Based Cistron Swapping into Lentiviral Expression Vectors. Biotechnology and Bioengineering 2004, 86 (2), 174-187.

Link: https://dx.doi.org/10.1002/bit.20028

Cellesi, F.Weber, WilfriedFussenegger, M.Hubbell, J. A.Tirelli, N.. Towards a fully synthetic substitute of alginate: Optimization of a thermal gelation/chemical cross-linking scheme ("tandem" gelation) for the production of beads and liquid-core capsules. Biotechnology and Bioengineering 2004, 88 (6), 740-749.

Link: https://dx.doi.org/10.1002/bit.20264

Kramer, B. P.Weber, WilfriedFussenegger, M.. Artificial regulatory networks and cascades for discrete multilevel transgene control in mammalian cells. Biotechnology and Bioengineering 2003, 83 (7), 810-820.

Link: https://dx.doi.org/10.1002/bit.10731

Weber, WilfriedMarty, R. R.Link, N.Ehrbar, M.Keller, B.Weber, C. C.Zisch, A. H.Heinzen, C.Djonov, V.Fussenegger, M.. Conditional human VEGF-mediated vascularization in chicken embryos using a novel temperature-inducible gene regulation (TIGR) system. Nucleic acids research 2003, 31 (12),

Link: https://dx.doi.org/10.1093/nar/gng069

Weber, WilfriedFussenegger, M.. Inducible gene expression in mammalian cells. New Comprehensive Biochemistry 2003, 38 589-604.

Link: https://dx.doi.org/10.1016/S0167-7306(03)38034-2

Fux, C.Weber, WilfriedDaoud-El Baba, M.Heinzen, C.Aubel, D.Fussenegger, M.. Novel macrolide-adjustable bidirectional expression modules for coordinated expression of two different transgenes in mice. Journal of Gene Medicine 2003, 5 (12), 1067-1079.

Link: https://dx.doi.org/10.1002/jgm.443

Weber, WilfriedSchoenmakers, R.Spielmann, M.El-Baba, M. D.Folcher, M.Keller, B.Weber, C. C.Link, N.van de Wetering, P.Heinzen, C.Jolivet, B.Séquin, U.Aubel, D.Thompson, C. J.Fussenegger, M.. Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice. Nucleic acids research 2003, 31 (14),

Link: https://dx.doi.org/10.1093/nar/gng071

Weber, WilfriedFussenegger, M.. Artificial mammalian gene regulation networks - Novel approaches for gene therapy and bioengineering. Journal of Biotechnology 2002, 98 (2-3), 161-187.

Link: https://dx.doi.org/10.1016/S0168-1656(02)00130-X

Weber, WilfriedFux, C.Daoud-El Baba, M.Keller, B.Weber, C. C.Kramer, B. P.Heinzen, C.Aubel, D.Bailey, J. E.Fussenegger, M.. Macrolide-based transgene control in mammalian cells and mice. Nature Biotechnology 2002, 20 (9), 901-907.

Link: https://dx.doi.org/10.1038/nbt731

Weber, WilfriedKramer, B. P.Fux, C.Keller, B.Fussenegger, M.. Novel promoter/transactivator configurations for macrolide- and streptogramin-responsive transgene expression in mammalian cells. Journal of Gene Medicine 2002, 4 (6), 676-686.

Link: https://dx.doi.org/10.1002/jgm.314

Weber, WilfriedWeber, E.Geisse, S.Memmert, K.. Optimisation of protein expression and establishment of the Wave Bioreactor for Baculovirus/insect cell culture. Cytotechnology 2002, 38 (1-3), 77-85.

Link: https://dx.doi.org/10.1023/A:1021102015070

Weber, WilfriedMarty, R. R.Keller, B.Rimann, M.Kramer, B. P.Fussenegger, M.. Versatile macrolide-responsive mammalian expression vectors for multiregulated multigene metabolic engineering. Biotechnology and Bioengineering 2002, 80 (6), 691-705.

Link: https://dx.doi.org/10.1002/bit.10461

Beitrag in Tagungsband

Ceren Ates, H.Schneider, N.Mohsenin, H.Weber, WilfriedUrban, G.Dincer, C.. Personalized antibiotherapy via ⇜finger prick⇝ blood test. In: MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, October 4-9, 2020, Virtual. CBMS; 2020: 1288-1289.

Ceren Ates, H.Schneider, N.Bruch, R.Weber, WilfriedUrban, G.Dincer, C.. Antibody-free assay for electrochemical ß-lactam monitoring. In: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 , October 27-31, 2019, Basel . CBMS; 2019: 1696-1697.

Bruch, R.Baaske, J.Chatelle, C.Weber, WilfriedDincer, C.Urban, G.. Electrochemical biosensor for CRISPR/Cas13a powered miRNA diagnostics. In: 2019 IEEE Sensors, October 27-30, 2019, Montreal . IEEE; 2019:

Link: https://dx.doi.org/10.1109/SENSORS43011.2019.8956561

Bruch, R.Baaske, J.Chatelle, C.Weber, WilfriedUrban, G. A.Dincer, C.. Microrna diagnostics on an electrochemical biosensor via CRISPR/CAS13A technology. In: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019, October 27-31, 2019, Basel . CBMS; 2019: 65-66.

Hömer, M.Hotz, N.Kaufmann, B.Gübeli, R.Christen, E.Büning, H.Grimm, D.Zurbriggen, M. D.Weber, Wilfried. Engineering light- and pharmacologically triggered extracellular biological switches. In: Synthetic Biology: Engineering, Evolution, and Design Conference 2015, SEED 2015, June 10-13, 2015, Boston . AIChE; 2015: 807.

Ketterer, S.Hoevermann, D.Weber, WilfriedMeier, M.. Metabolite analytics with an integrated protein sensor on a microfluidic chip. In: 17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, October 27-31, 2013, Freiburg . CBMS; 2013: 868-870.

Beitrag in Buch

Wagner, H. J.Mohsenin, H.Weber, Wilfried. Synthetic Biology-Empowered Hydrogels for Medical Diagnostics. In:Lavrentieva, Antonia, eds. Tunable Hydrogels : smart materials for biomedical applications. 2021: 197-226

Link: https://dx.doi.org/10.1007/10_2020_158

Rebmann, B.van Hoogevest, P.Matias, Z.Weber, Wilfried. Pharmaceutical aspects of biologics from animal cell culture processes: Spatiotemporally controlled delivery of biopharmaceuticals. In:Hauser, Hans-Jörg, eds. Animal Cell Biotechnology: In Biologics Production. 2014: 649-692

Link: https://dx.doi.org/10.1515/9783110278965.649

Weber, WilfriedFussenegger, M.. Towards genetically designed tissues for regenerative medicine. In:Meyer, Ulrich, eds. Fundamentals of Tissue Engineering and Regenerative Medicine. 2009: 93-108

Link: https://dx.doi.org/10.1007/978-3-540-77755-7_9

Weber, WilfriedFussenegger, M.. Baculovirus-based Production of Biopharmaceuticals using Insect Cell Culture Processes. In:Knäblein, Jörg, eds. Modern Biopharmaceuticals: Design, Development and Optimization. 2008: 1045-1062

Link: https://dx.doi.org/10.1002/9783527620982.ch44

Weber, WilfriedFussenegger, M.. Novel gene switches. In:Kauser, Katalin, eds. Handbook of Experimental Pharmacology. 2007: 73-105

Link: https://dx.doi.org/10.1007/978-3-540-35109-2_4

Preprint

Hörner, MaximilianBecker, JanBohnert, RebeccaBanos, MiguelJerez-Longres, CarolinaMühlhäuser, VanessaHärrer, DanielWang Wong, TinMeier, MatthiasWeber, Wilfried. A photoreceptor-based hydrogel with red light-responsive reversible sol-gel transition as transient cellular matrix. bioRxiv 2023,

Link: https://www.biorxiv.org/content/10.1101/2023.04.04.535523v1.full.pdf

Jerez-Logres, CarolinaGómez-Matos, MarietaBecker, JanHörner, MaximilianWieland, Franz-GeorgTimmer, JensWeber, Wilfried. Engineering a material-genetic interface as safety switch for embedded therapeutic cells. BioRxiv 2023,

Link: https://www.biorxiv.org/content/10.1101/2023.04.03.535359v1