{"id":33156,"date":"2024-05-21T14:26:47","date_gmt":"2024-05-21T14:26:47","guid":{"rendered":"https:\/\/www.leibniz-inm.de\/?post_type=events&p=33156"},"modified":"2024-05-21T14:29:56","modified_gmt":"2024-05-21T14:29:56","slug":"engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications","status":"publish","type":"events","link":"https:\/\/www.leibniz-inm.de\/en\/events\/engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications\/","title":{"rendered":"Engineering lipid membranes: From biophysicalproperties to biotechnological applications"},"content":{"rendered":"\n

Abstract<\/h2>\n\n\n\n

The biophysical properties of lipid vesicles are important for their stability and integrity, key parameters that control the performance when these vesicles are used for drug delivery. The lipid vesicle properties are determined by the composition and arrangement of lipids used to form the vesicle. However, the symmetric structure of the lipid bilayer limits the tailoring of their biophysical and biochemical properties. Here, we present a novel approach for the design of asymmetric lipid vesicles with arbitrary lipid compositions. Compared to symmetric lipid vesicles, we find that asymmetric lipid vesicles lead to higher cell uptake and mRNA transfection while having a reduced cell cytotoxicity. We also show that the lipid vesicle properties for a given lipid composition can be tailored by asymmetrically tethering polysaccharides to the membrane. Overall, asymmetric lipid vesicles provide the means to fine-tune and tailor drug delivery carriers to enable the next generation of disease treatment and vaccine technology.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"event-categories":[120],"class_list":["post-33156","events","type-events","status-publish","hentry","event-categories-seminar-en"],"acf":[],"yoast_head":"\nEngineering lipid membranes: From biophysicalproperties to biotechnological applications - INM<\/title>\n<meta name=\"description\" content=\"Engineering lipid membranes: From biophysicalproperties to biotechnological applications \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.leibniz-inm.de\/en\/events\/engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Engineering lipid membranes: From biophysicalproperties to biotechnological applications - INM\" \/>\n<meta property=\"og:description\" content=\"Engineering lipid membranes: From biophysicalproperties to biotechnological applications \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.leibniz-inm.de\/en\/events\/engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications\/\" \/>\n<meta property=\"og:site_name\" content=\"INM\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-21T14:29:56+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.leibniz-inm.de\/wp-content\/uploads\/2024\/03\/INM-Logo-Regular_en.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1085\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Leibniz_INM\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications\\\/\",\"url\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/engineering-lipid-membranes-from-biophysicalproperties-to-biotechnological-applications\\\/\",\"name\":\"Engineering lipid membranes: From biophysicalproperties to biotechnological applications - 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