{"id":24025,"date":"2023-01-20T13:24:08","date_gmt":"2023-01-20T13:24:08","guid":{"rendered":"https:\/\/www.leibniz-inm.de\/events\/cell-growth-under-mechanical-pressure-2\/"},"modified":"2024-05-14T12:36:34","modified_gmt":"2024-05-14T12:36:34","slug":"cell-growth-under-mechanical-pressure","status":"publish","type":"events","link":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/","title":{"rendered":"Cell Growth under Mechanical Pressure"},"content":{"rendered":"<p>Dr. Morgan Delarue<\/p>\n<p>Universit\u00e9 Toulouse, team MILE, LAAS-CNRS, France<\/p>\n<p>Host: Prof. Dr. Ar\u00e1nzazu del Campo<\/p>\n<p><!--more--><\/p>\n<p>We will send you the zoom link on request.<\/p>\n<p>Contact: Christine Hartmann<br \/>\n<a href=\"mailto:christine.hartmann@leibniz-inm.de\">christine.hartmann@leibniz-inm.de<\/a><br \/>\nPhone: ++49 (0)681 9300 244<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Cells act upon the elastic extracellular matrix and against steric constraints when growing in a spatially-limited environment. At the multicellular level, confined cell proliferation results in the emergence of a compressive, growth-induced, mechanical stress. Compressive stresses are ubiquitous to any cell population developing in confinement, such as most solid tumors or microbes, and can deeply impact cell physiology. In this talk, we will mainly be focusing on the impact of growth-induced pressure on a model organism, the budding yeast <em>S. cerevisiae. <\/em><\/p>\n<p>We observed that the growth of <em>S. cerevisiae<\/em> decreased under pressure. Using novel genetically-encoded nanoparticles (GEMs) to assess the rheological properties of a cell, we show that compressive stress alters the motion of macromolecules inside the cell, in a size-specific manner. Under compression, reactions such as protein synthesis can become diffusion-limited, globally decreasing the dynamics of biomass production, and elucidating a mechanism in which growth limitation can be attributed to modifications in the rheological properties of cells.<\/p>\n<p>At the end of the talk, we will explore the possibility that the cytosolic rheological properties are partly conserved across organisms. This result can expand the observations made on <em>S. cerevisiae<\/em> to other organisms such as bacteria and mammalian cells, and point towards a universally-conserved biophysical mechanism regulating growth under pressure.<\/p>\n<p><strong>Short CV<\/strong><\/p>\n<p>Morgan Delarue is a biophysicist working at LAAS-CNRS in Toulouse, France. Their research lies at the interface between physics, engineering, biology and medicine, and aims at the understanding of the physiological response to compressive stress in different organisms, with a particular emphasis on cancer.<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"_acf_changed":false,"footnotes":""},"event-categories":[86],"class_list":["post-24025","events","type-events","status-publish","hentry","event-categories-colloquium"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cell Growth under Mechanical Pressure - INM<\/title>\n<meta name=\"description\" content=\"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cell Growth under Mechanical Pressure - INM\" \/>\n<meta property=\"og:description\" content=\"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/\" \/>\n<meta property=\"og:site_name\" content=\"INM\" \/>\n<meta property=\"article:modified_time\" content=\"2024-05-14T12:36:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.leibniz-inm.de\/wp-content\/uploads\/2024\/03\/INM-Logo-Regular_en.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"1085\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@Leibniz_INM\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/cell-growth-under-mechanical-pressure\\\/\",\"url\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/cell-growth-under-mechanical-pressure\\\/\",\"name\":\"Cell Growth under Mechanical Pressure - INM\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#website\"},\"datePublished\":\"2023-01-20T13:24:08+00:00\",\"dateModified\":\"2024-05-14T12:36:34+00:00\",\"description\":\"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/cell-growth-under-mechanical-pressure\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/cell-growth-under-mechanical-pressure\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/cell-growth-under-mechanical-pressure\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Events\",\"item\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/events\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Cell Growth under Mechanical Pressure\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/\",\"name\":\"INM\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#organization\"},\"alternateName\":\"Leibniz Institute for New Materials\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#organization\",\"name\":\"Leibniz Institute for New Materials\",\"url\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.leibniz-inm.de\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/INM-Logo-Regular_en.png\",\"contentUrl\":\"https:\\\/\\\/www.leibniz-inm.de\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/INM-Logo-Regular_en.png\",\"width\":1200,\"height\":1085,\"caption\":\"Leibniz Institute for New Materials\"},\"image\":{\"@id\":\"https:\\\/\\\/www.leibniz-inm.de\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/x.com\\\/Leibniz_INM\",\"https:\\\/\\\/www.instagram.com\\\/leibniz_inm\\\/\",\"https:\\\/\\\/www.youtube.com\\\/@leibniz_inm\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/inm-leibniz-institute-for-new-materials\\\/\",\"https:\\\/\\\/bsky.app\\\/profile\\\/leibnizinm.bsky.social\"]}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cell Growth under Mechanical Pressure - INM","description":"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/","og_locale":"en_US","og_type":"article","og_title":"Cell Growth under Mechanical Pressure - INM","og_description":"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).","og_url":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/","og_site_name":"INM","article_modified_time":"2024-05-14T12:36:34+00:00","og_image":[{"width":1200,"height":1085,"url":"https:\/\/www.leibniz-inm.de\/wp-content\/uploads\/2024\/03\/INM-Logo-Regular_en.png","type":"image\/png"}],"twitter_card":"summary_large_image","twitter_site":"@Leibniz_INM","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/","url":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/","name":"Cell Growth under Mechanical Pressure - INM","isPartOf":{"@id":"https:\/\/www.leibniz-inm.de\/en\/#website"},"datePublished":"2023-01-20T13:24:08+00:00","dateModified":"2024-05-14T12:36:34+00:00","description":"Cell Growth under Mechanical Pressure \u2013 Eine Veranstaltung des Leibniz-Instituts f\u00fcr Neue Materialien (INM).","breadcrumb":{"@id":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.leibniz-inm.de\/en\/events\/cell-growth-under-mechanical-pressure\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.leibniz-inm.de\/en\/"},{"@type":"ListItem","position":2,"name":"Events","item":"https:\/\/www.leibniz-inm.de\/en\/events\/"},{"@type":"ListItem","position":3,"name":"Cell Growth under Mechanical Pressure"}]},{"@type":"WebSite","@id":"https:\/\/www.leibniz-inm.de\/en\/#website","url":"https:\/\/www.leibniz-inm.de\/en\/","name":"INM","description":"","publisher":{"@id":"https:\/\/www.leibniz-inm.de\/en\/#organization"},"alternateName":"Leibniz Institute for New Materials","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.leibniz-inm.de\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.leibniz-inm.de\/en\/#organization","name":"Leibniz Institute for New Materials","url":"https:\/\/www.leibniz-inm.de\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.leibniz-inm.de\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.leibniz-inm.de\/wp-content\/uploads\/2024\/03\/INM-Logo-Regular_en.png","contentUrl":"https:\/\/www.leibniz-inm.de\/wp-content\/uploads\/2024\/03\/INM-Logo-Regular_en.png","width":1200,"height":1085,"caption":"Leibniz Institute for New Materials"},"image":{"@id":"https:\/\/www.leibniz-inm.de\/en\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/x.com\/Leibniz_INM","https:\/\/www.instagram.com\/leibniz_inm\/","https:\/\/www.youtube.com\/@leibniz_inm\/","https:\/\/www.linkedin.com\/company\/inm-leibniz-institute-for-new-materials\/","https:\/\/bsky.app\/profile\/leibnizinm.bsky.social"]}]}},"_links":{"self":[{"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/events\/24025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/events"}],"about":[{"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/types\/events"}],"version-history":[{"count":3,"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/events\/24025\/revisions"}],"predecessor-version":[{"id":32658,"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/events\/24025\/revisions\/32658"}],"wp:attachment":[{"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/media?parent=24025"}],"wp:term":[{"taxonomy":"event-categories","embeddable":true,"href":"https:\/\/www.leibniz-inm.de\/en\/wp-json\/wp\/v2\/event-categories?post=24025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}